Subthalamic deep brain stimulation effects on odor identification in Parkinson's disease

Authors

  • M. Fabbri,

    1. IRCCS Institute of Neurological Science, Bologna, Italy
    2. Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
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  • L. C. Guedes,

    1. Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
    2. Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
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  • M. Coelho,

    1. Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
    2. Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
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  • D. Simão,

    1. Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
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  • D. Abreu,

    1. Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
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  • M. M. Rosa,

    1. Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
    2. Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
    3. Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
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  • L. Silveira-Moriyama,

    1. Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
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  • J. J. Ferreira

    Corresponding author
    1. Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
    2. Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
    3. Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
    • Correspondence: J. Ferreira, Neurological Clinic Research Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Av. Prof Egas Moniz, 1649-035 Lisbon, Portugal (tel.: +351 21 7973453; fax: +351 21 7802129; e-mail: joaquimjferreira@gmail.com).

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Abstract

Background and purpose

Olfactory dysfunction is common in Parkinson's disease (PD) and it is one of the earliest non-motor symptoms. A few studies have suggested that deep brain stimulation of the subthalamic nucleus (STN-DBS) could improve olfactory function. Our aim was to evaluate the acute effect of bilateral STN-DBS on a commonly used smell test in PD patients.

Methods

Fifteen PD patients who underwent bilateral STN-DBS and 15 controls were recruited. Patients and controls were tested for odor identification.

Results

No statistical differences were documented between ON and OFF STN-DBS acute stimulation concerning olfaction. Controls presented a better performance for olfactory identification than patients.

Conclusions

Our exploratory study did not support that bilateral STN-DBS could have an acute effect on olfactory function in PD patients.

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