Risk of accidental injuries amongst Parkinson disease patients

Authors

  • H.-C. Wang,

    1. Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
    2. College of Medicine, National Taiwan University, Taipei, Taiwan
    3. College of Medicine, Taipei Medical University, Taipei, Taiwan
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  • C.-C. Lin,

    1. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
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  • C.-I. Lau,

    1. Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
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  • A. Chang,

    1. Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
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  • F.-C. Sung,

    1. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
    2. Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
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  • C.-H. Kao

    Corresponding author
    1. Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
    2. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
    • Correspondence: C.-H. Kao, Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan (tel.: +886 4 22052121 x7412; fax: +886 4 22336174; e-mail: d10040@mail.cmuh.org.tw).

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Abstract

Background and purpose

To investigate the spectrum and risks of accidental injuries (AIs) amongst Parkinson disease (PD) patients.

Methods

The participants comprised PD patients aged 50 years and older who were initially diagnosed between 2000 and 2009, and a comparison group of non-PD patients. The incidence rates of accidental injury types amongst PD and non-PD patients were calculated; hazard ratios were calculated and adjusted for comorbidities, using 95% confidence intervals (CIs) of developing such outcomes in PD patients.

Results

In total, 4046 PD patients and 16 184 non-PD patients were followed over time. The PD patients demonstrated the following incidence rates and hazard ratios in comparison to the control cohort for accidental injuries: all injuries, 19.78 per 100 person-years (100 PYs), adjusted hazard ratio (HR) 1.30 (95% CI 1.24–1.36); head injury, 2.95 per 100 PYs, HR 1.88 (95% CI 1.64–2.15); bone fracture and dislocation, 4.61 per 100 PYs, HR 1.39 (95% CI 1.25–1.54); burns, 0.66 per 100 PYs, HR 1.01 (95% CI 0.78–1.32); injury to spinal cord, plexus and nerves, 0.15 per 100 PYs, HR 1.25 (95% CI 0.72–2.17); superficial injuries and contusions, 11.41 per 100 PYs, HR 1.20 (95% CI 1.12–1.27). The injury risk for the 69–79 years age group in PD compared with controls of the same age (HR 1.38) was significantly higher compared with that of the 50–69 age groups in PD and controls (HR 1.16).

Conclusions

Parkinson disease patients demonstrate a significantly elevated risk of developing all accidental injury types except burn injuries and injuries to spinal cord, plexus and nerves, compared with age-matched controls. The risk increases as age increases.

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