Mortality by clinical characteristics in a tertiary care cohort of adult patients with chronic epilepsy
Article first published online: 25 OCT 2012
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy
Volume 53, Issue 12, pages e212–e214, December 2012
How to Cite
Nevalainen, O., Auvinen, A., Ansakorpi, H., Artama, M., Raitanen, J. and Isojärvi, J. (2012), Mortality by clinical characteristics in a tertiary care cohort of adult patients with chronic epilepsy. Epilepsia, 53: e212–e214. doi: 10.1111/epi.12006
- Issue published online: 3 DEC 2012
- Article first published online: 25 OCT 2012
- Accepted September 3, 2012; Early View publication October 25, 2012.
- Potential years of life lost;
The authors evaluated the contribution of various clinical characteristics to mortality risk and underlying causes of death among all adult patients with epilepsy seen at the Department of Neurology, Oulu University Hospital in Finland during 1996 and 1997. Hazard ratios (HRs) for mortality in 1998–2006 relative to a population-based reference cohort were estimated using Cox modeling, with adjustment for age and gender. The HR for total mortality was 2.66 (95% confidence interval [CI] 2.09–3.39). Infectious etiology of epilepsy (HR 5.77, 95% CI 2.52–13.2) and a seizure frequency of ≥1 per month (HR 4.42, 95% CI 3.00–6.52) related to high risks of death. Cancer (21%), ischemic heart disease (15%), and accidents (12%) caused most of the potential years of life lost. Despite recent advances in treatment of epilepsy and improved seizure control, chronic epilepsy still carries a substantially increased risk of death.