Mesial temporal lobe epilepsy as a neuropsychiatric syndrome of systemic lupus erythematosus
Article first published online: 5 NOV 2012
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy
Volume 54, Issue 3, pages e33–e36, March 2013
How to Cite
Toyota, T., Akamatsu, N., Tanaka, A., Shouzaki, T., Tsuji, S., Saito, K. and Tanaka, Y. (2013), Mesial temporal lobe epilepsy as a neuropsychiatric syndrome of systemic lupus erythematosus. Epilepsia, 54: e33–e36. doi: 10.1111/epi.12012
- Issue published online: 4 MAR 2013
- Article first published online: 5 NOV 2012
- Accepted September 10, 2012; Early View publication Xxxxxx XX, 2012.
- Systemic lupus erythematosus;
- Neuropsychiatric syndrome of systemic lupus erythematosus;
- Mesial temporal lobe epilepsy;
In this study, we aimed to investigate the types of seizures and epilepsy associated with systemic lupus erythematosus (SLE). We searched the medical records at a tertiary referral center to identify a cohort of epilepsy patients with SLE who were treated between January 2000 and August 2011. We analyzed the clinical and immunologic profiles of these patients, their seizure and epilepsy classifications, electroencephalography (EEG) and magnetic resonance imaging (MRI) assessments, and the treatment administered for epilepsy and SLE. As the result, 17 patients with SLE and epilepsy were identified. Seven patients had mesial temporal lobe epilepsy (MTLE), eight had epilepsy secondary to stroke, and two had generalized epilepsy. Of the seven patients with MTLE, anteriotemporal spikes were noted in all patients with EEG, and MRI findings suggesting hippocampal sclerosis were noted in four patients. Clobazam and levetiracetam were effective in treating three patients, and one patient underwent amygdalohippocampectomy. In conclusion, MTLE may be a characteristic manifestation of neuropsychiatric syndrome of systemic lupus erythematosus.