Premature mortality risk in people with convulsive epilepsy: Long follow-up of a cohort in rural China

Authors


  • Ding Ding and Wenzhi Wang contributed equally to this paper.

Address correspondence to Zhen Hong, Institute of Neurology, Huashan Hospital, Fudan University, #12 Wulumuqi Zhong Rd., Shanghai 200040, China. E-mail: profzhong@sina.com
Ley Sander, UCL Institute of Neurology, Box 29, Queen Square, London WC1N 3BG, U.K. E-mail: l.sander@ucl.ac.uk

Summary

Purpose:  Detailed data on the mortality of epilepsy are still lacking from resource-poor settings. We conducted a long-term follow-up survey in a cohort of people with convulsive epilepsy in rural areas of China. In this longitudinal prospective study we investigated the causes of death and premature mortality risk among people with epilepsy.

Methods:  We attempted to trace all 2,455 people who had previously participated in a pragmatic assessment of epilepsy management at the primary health level. Putative causes of death were recorded for those who died, according to the International Classification of Diseases. We estimated proportional mortality ratios (PMRs) for each cause, and standardized mortality ratios (SMRs) for each age-group and cause. Survival analysis was used to detect risk factors associated with increased mortality.

Key Findings:  During 6.1 years of follow-up there were 206 reported deaths among the 1,986 people with epilepsy who were located. The highest PMRs were for cerebrovascular disease (15%), drowning (14%), self-inflicted injury (13%), and status epilepticus (6%), with probable sudden unexpected death in epilepsy (SUDEP) in 1%. The risk of premature death was 2.9 times greater in people with epilepsy than in the general population. A much higher risk (SMRs 28–37) was found in young people. Duration of epilepsy and living in a waterside area were independent predictors for drowning.

Significance:  Drowning and status epilepticus were important, possibly preventable, causes of death. Predictors of increasing mortality suggest interventions with efficient treatment and education to prevent premature mortality among people with epilepsy in resource-poor settings.

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