This study was presented as a platform presentation at the “Joint Congress of the 12th International Child Neurology Congress and the 11th Asian and Oceanian Congress of Child Neurology.” held at Brisbane, Australia, 27 May–1 June 2012.
Full-Length Original Research
Use of the modified Atkins diet for treatment of refractory childhood epilepsy: A randomized controlled trial
Article first published online: 7 JAN 2013
Wiley Periodicals, Inc. © 2013 International League Against Epilepsy
Volume 54, Issue 3, pages 481–486, March 2013
How to Cite
Sharma, S., Sankhyan, N., Gulati, S. and Agarwala, A. (2013), Use of the modified Atkins diet for treatment of refractory childhood epilepsy: A randomized controlled trial. Epilepsia, 54: 481–486. doi: 10.1111/epi.12069
- Issue published online: 4 MAR 2013
- Article first published online: 7 JAN 2013
- Manuscript Accepted: 6 NOV 2012
- Council for Scientific and Industrial Research (CSIR), Govt. of India
- Ketogenic diet;
- Dietary therapies;
- Epilepsy surgery
The aim of this study was to evaluate the efficacy of the modified Atkins diet in a randomized controlled trial in children with refractory epilepsy.
Children aged 2–14 years who had daily seizures despite the appropriate use of at least three anticonvulsant drugs were enrolled. Children were randomized to receive either the modified Atkins diet or no dietary intervention for a period of 3 months. The ongoing anticonvulsant medications were continued unchanged in both the groups. Seizure control at 3 months was the primary end point. Analysis was intention to treat. Adverse effects of the diet were assessed by parental reports (ClinicalTrials.gov Identifier: NCT00836836).
Among a total of 102 children, 50 were in the diet group and 52 in the control group. Four children discontinued the diet before the study end point, and three children in the control group were lost to follow-up. The mean seizure frequency at 3 months, expressed as a percentage of the baseline, was significantly less in the diet group: 59 ± 54 (95% confidence interval [CI] 44–74.5) versus 95.5 ± 48 (95% CI 82–109), p = 0.003. The proportion of children with >90% seizure reduction (30% vs. 7.7%, p = 0.005) and >50% seizure reduction was significantly higher in the diet group (52% vs. 11.5%, p < 0.001). Constipation was the most common adverse effect among children on the diet (23, 46%).
The modified Atkins diet was found to be effective and well tolerated in children with drug-refractory epilepsy.