Treatment issues for personality disorders in epilepsy


Address correspondence to Michael Trimble, FRCP, Box 148, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, U.K. E-mail:


This article supports a view that certain personality disturbances in epilepsy should be viewed as associated with the cerebral abnormalities that also lead to seizures. Herein I discuss two main variants: that related to temporal lobe epilepsy and that associated with juvenile myoclonic epilepsy. In view of its controversial nature, I also comment on the link between aggression and epilepsy. Recommendations for treatment include psychological and social therapies with further advice about the use of antiepileptic drugs (AEDs) and psychotropic medications in these conditions.