Management of psychogenic nonepileptic seizures


Address correspondence to W. Curt LaFrance, Jr, Neuropsychiatry and Behavioral Neurology Division, Departments of Neurology and Psychiatry, Rhode Island Hospital, 593 Eddy St., Providence, RI 02903, U.S.A. E-mail:


The International League Against Epilepsy (ILAE) Neuropsychobiology Commission gave the charge to provide practical guidance for health professionals for the pharmacologic and nonpharmacologic treatment of patients with psychogenic nonepileptic seizures (PNES). Using a consensus review of the literature, an international group of clinician-researchers in epilepsy, neurology, neuropsychology, and neuropsychiatry evaluated key management approaches for PNES. These included the following: presentation of the diagnosis, early phase treatment, psychological and pharmacologic interventions, and maintenance management. The aim of this report is to provide greater clarity about the range and current evidence base for treatment for patients with PNES, with the intention of improving the care of patients with PNES and patients who develop PNES as a comorbidity of epilepsy.