Full-Length Original Research
Adherence to antiepileptic medicines in children: A multiple-methods assessment involving dried blood spot sampling
Version of Record online: 28 FEB 2013
Wiley Periodicals, Inc. © 2013 International League Against Epilepsy
Volume 54, Issue 6, pages 1020–1027, June 2013
How to Cite
Shah, N. M., Hawwa, A. F., Millership, J. S., Collier, P. S., Ho, P., Tan, M. L., Peake, D., Tirupathi, S., Bothwell, J., Bailie, N., Shepherd, C., Craig, J. and McElnay, J. C. (2013), Adherence to antiepileptic medicines in children: A multiple-methods assessment involving dried blood spot sampling. Epilepsia, 54: 1020–1027. doi: 10.1111/epi.12126
- Issue online: 4 JUN 2013
- Version of Record online: 28 FEB 2013
- Manuscript Accepted: 17 JAN 2013
- British Council under the Prime Minister's II Initiative award
- Atlantic Philanthropies
- Dried blood spots;
- MARS ;
- Depressed mood
To evaluate adherence to prescribed antiepileptic drugs (AEDs) in children with epilepsy using a combination of adherence-assessment methods.
A total of 100 children with epilepsy (≤17 years old) were recruited. Medication adherence was determined via parental and child self-reporting (≥9 years old), medication refill data from general practitioner (GP) prescribing records, and via AED concentrations in dried blood spot (DBS) samples obtained from children at the clinic and via self- or parental-led sampling in children's own homes. The latter were assessed using population pharmacokinetic modeling. Patients were deemed nonadherent if any of these measures were indicative of nonadherence with the prescribed treatment. In addition, beliefs about medicines, parental confidence in seizure management, and the presence of depressed mood in parents were evaluated to examine their association with nonadherence in the participating children.
The overall rate of nonadherence in children with epilepsy was 33%. Logistic regression analysis indicated that children with generalized epilepsy (vs. focal epilepsy) were more likely (odds ratio [OR] 4.7, 95% confidence interval [CI] 1.37–15.81) to be classified as nonadherent as were children whose parents have depressed mood (OR 3.6, 95% CI 1.16–11.41).
This is the first study to apply the novel methodology of determining adherence via AED concentrations in clinic and home DBS samples. The present findings show that the latter, with further development, could be a useful approach to adherence assessment when combined with other measures including parent and child self-reporting. Seizure type and parental depressed mood were strongly predictive of nonadherence.