Full-Length Original Research
Structural correlates of impaired working memory in hippocampal sclerosis
Article first published online: 24 APR 2013
© 2013 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 54, Issue 7, pages 1143–1153, July 2013
How to Cite
Winston, G. P., Stretton, J., Sidhu, M. K., Symms, M. R., Thompson, P. J. and Duncan, J. S. (2013), Structural correlates of impaired working memory in hippocampal sclerosis. Epilepsia, 54: 1143–1153. doi: 10.1111/epi.12193
- Issue published online: 1 JUL 2013
- Article first published online: 24 APR 2013
- Manuscript Accepted: 11 MAR 2013
- Wellcome Trust. Grant Number: 083148
- Medical Research Council. Grant Number: G0802012
- Big Lottery Fund
- Wolfson Trust and Epilepsy Society
- Department of Health's NIHR Biomedical Research Centres funding scheme
|epi12193-sup-0001-TableS1-S4.docx||Word document||20K|| |
Table S1. Regions of GMV loss in patients compared to healthy controls (uncorrected p = 0.001, 10 voxel clusters = 33.75 mm3).
Table S2. Regions where GMV correlated with working memory performance (uncorrected p = 0.001, 10 voxel clusters = 33.75 mm3).
Table S3. Regions where FA correlated with working memory performance (uncorrected p = 0.001, age as covariate, 10 voxel clusters = 10 mm3).
Table S4. Regions where MD correlated with working memory performance (uncorrected p = 0.001, age as covariate, 10 voxel clusters = 10 mm3).
|epi12193-sup-0002-FigureS1.tif||image/tif||2691K||Figure S1. (A) A bilateral frontoparietal working memory network was identified using the 2-back minus 0-back contrast in all subjects. (B) In both LHS and RHS groups there was significantly less activation in the right SPL compared to controls (uncorrected p = 0.001, conjunction).|
|epi12193-sup-0003-FigureS2.tif||image/tif||13259K||Figure S2. In LHS, better working memory performance correlated with lower MD in the frontoparietal working memory network (left SFG, A and B; bilateral SPL, A and C), the right cingulum (D), and the right orbitofrontal cortex (not shown).|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.