Time-frequency mapping of the rhythmic limb movements distinguishes convulsive epileptic from psychogenic nonepileptic seizures

Authors

  • Jade Bayly,

    1. Department of Neurology , The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
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  • John Carino,

    1. Department of Neurology , The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
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  • Slavé Petrovski,

    1. Department of Medicine, The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
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  • Michelle Smit,

    1. Department of Neurology , The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
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  • Dilini A. Fernando,

    1. Department of Neurology , The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    2. Department of Medicine, The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
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  • Anita Vinton,

    1. Department of Neurology , The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    2. Department of Medicine, The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
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  • Bernard Yan,

    1. Department of Neurology , The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    2. Department of Medicine, The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
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  • Jayavardhana R. Gubbi,

    1. Department of Electrical Engineering, The University of Melbourne, Parkville, Victoria, Australia
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  • Marimuthu S. Palaniswami,

    1. Department of Electrical Engineering, The University of Melbourne, Parkville, Victoria, Australia
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  • Terence J. O'Brien

    Corresponding author
    1. Department of Neurology , The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    2. Department of Medicine, The Melbourne Brain Centre, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    • Address correspondence to Terence O'Brien, The Department of Medicine, The Royal Melbourne Hospital, Royal Parade, Parkville 3050, Vic., Australia. E-mail: obrientj@unimelb.edu.au

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Summary

Purpose

A definite diagnosis of psychogenic nonepileptic seizures (PNES) usually requires in-patient video–electroencephalography (EEG) monitoring. Previous research has shown that convulsive psychogenic nonepileptic seizures (PNES) demonstrate a characteristic pattern of rhythmic movement artifact on the EEG. Herein we sought to examine the potential for time-frequency mapping of data from a movement-recording device (accelerometer) worn on the wrist as a diagnostic tool to differentiate between convulsive epileptic seizures and PNES.

Methods

Time-frequency mapping was performed on accelerometer traces obtained during 56 convulsive seizure-like events from 35 patients recorded during in-patient video-EEG monitoring. Twenty-six patients had PNES, eight had epileptic seizures, and one had both seizure types. The time-frequency maps were derived from fast Fourier transformations to determine the dominant frequency for sequential 2.56-s blocks for the course of each event.

Key Findings

The coefficient of variation (CoV) of limb movement frequency for the PNES events was less than for the epileptic seizure events (median, 17.18% vs. 52.23%; p < 0.001). A blinded review of the time-frequency maps by an epileptologist was accurate in differentiating between the event types, that is, 38 (92.7%) of 41 and 6 (75%) of 8 nonepileptic and epileptic seizures, respectively, were diagnosed correctly, with seven events classified as “nondiagnostic.” Using a CoV cutoff score of 32% resulted in similar classification accuracy, with 42 (93%) of 45 PNES and 10 (91%) of 11 epileptic seizure events correctly diagnosed.

Significance

Time-frequency analysis of data from a wristband movement monitor could be utilized as a diagnostic tool to differentiate between epileptic and nonepileptic convulsive seizure-like events.

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