Full-Length Original Research
Prognostic value of insular lobe involvement in temporal lobe epilepsy: A stereoelectroencephalographic study
Article first published online: 12 JUL 2013
Wiley Periodicals, Inc. © 2013 International League Against Epilepsy
Volume 54, Issue 9, pages 1658–1667, September 2013
How to Cite
Blauwblomme, T., David, O., Minotti, L., Job, A.-S., Chassagnon, S., Hoffman, D., Chabardes, S. and Kahane, P. (2013), Prognostic value of insular lobe involvement in temporal lobe epilepsy: A stereoelectroencephalographic study. Epilepsia, 54: 1658–1667. doi: 10.1111/epi.12260
- Issue published online: 6 SEP 2013
- Article first published online: 12 JUL 2013
- Manuscript Accepted: 27 MAY 2013
- Temporal lobe epilepsy;
- Stereotactic intracerebral electroencephalographic;
- Epileptogenic index;
- Epilepsy surgery
Failure of anterior temporal lobectomy for temporal lobe epilepsy has raised the question of insular cortex involvement in these seizures. Because of difficulties in exploring the insula with invasive electroencephalography (EEG) recordings, only few studies have been performed and this question remains unanswered.
Here, we studied 17 patients who underwent surgery for drug-resistant temporal lobe epilepsy, explored with intracerebral electrodes, with at least one electrode coplanar to the insula. We analyzed seizure propagation patterns from temporal lobe structures to the insula, and their effect on outcome. We used an objective measure of the epileptogenicity of the insula for individual cases and group analysis between patients who were seizure-free after surgery and the others.
All temporal lobe seizures propagated to the insular cortex, with a shorter propagation delay in the case of mesiolateral temporal lobe seizures, thus supporting the existence of a perilimbic network. Epileptogenicity of the insular cortex was not a prognostic factor for outcome after surgery.
Insular involvement in temporal lobe seizure is not per se a prognostic factor for surgical outcome. Prognosis may be correlated with larger epileptogenic zones that our stereoelectroencephalography spatial sampling could have underestimated.