Autoimmunity, seizures, and status epilepticus

Authors

  • Rebecca Davis,

    1. Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A
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  • Josep Dalmau

    Corresponding author
    1. Catalan Institution for Research and Advanced Studies (ICREA), Hospital Clinic, University of Barcelona, Barcelona, Spain
    2. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain
    • Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A
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Address correspondence to Josep Dalmau, ICREA-IDIBAPS, Hospital Clinic, University of Barcelona, Department of Neurology, c/ Villarroel 170, Barcelona 08036, Spain. E-mail: josep.dalmau@uphs.upenn.edu

Summary

The recent discovery of a category of autoimmune encephalitis associated with antibodies against neuronal cell-surface and synaptic proteins has renewed interest for autoimmune causes of epilepsy. The identification of autoimmune encephalitis has changed paradigms in the diagnosis and management of several novel and treatable syndromes that occur with seizures and status epilepticus previously attributed to viral or idiopathic etiologies. This review focuses on the novel group of autoimmune encephalitis and also discusses some classical paraneoplastic syndromes that constitute another group of autoimmune disorders that may result in seizures.

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