Status epilepticus 2013
Multimodal invasive monitoring in status epilepticus: What is the evidence it has a place?
Article first published online: 3 SEP 2013
Wiley Periodicals, Inc. © 2013 International League Against Epilepsy
Special Issue: Current advances and future directions in status epilepticus: The proceedings of the fourth London-Innsbruck-Colloquium on Status Epilepticus Salzburg, Austria—April 4–6, 2013
Volume 54, Issue Supplement s6, pages 57–60, September 2013
How to Cite
Helbok, R. and Claassen, J. (2013), Multimodal invasive monitoring in status epilepticus: What is the evidence it has a place?. Epilepsia, 54: 57–60. doi: 10.1111/epi.12279
- Issue published online: 3 SEP 2013
- Article first published online: 3 SEP 2013
- Electrographic seizures;
- Status epilepticus;
- Multimodality monitoring;
- Continuous EEG monitoring;
- Brain metabolism
The underlying pathophysiology of status epilepticus (SE) remains mostly invisible to the clinician in the intensive care unit (ICU) setting. In animal studies associated hemodynamic and brain neurochemical changes have been well described. In the last decade, bedside invasive neuromonitoring techniques allow the assessments of changes in focal and global cerebral physiology associated with ictal activity on the tissue level in humans. Recent studies demonstrate that laboratory research insufficiently replicates the complexity of the human condition. Herein we summarize the current knowledge gained from human studies integrating cortical electrographic and brain tissue metabolic and hemodynamic information into the current pathophysiologic concept of SE in humans. With increasing experience gained by the use of extended neuromonitoring, we are more and more able to understand associated hemodynamic and brain neurochemical changes in patients with SE. In the future, this information can potentially provide integrated pathophysiologic end points into SE treatment concepts.