The bromides were the first strikingly effective antiepileptic drugs, and their introduction in the 1860s coincided with the first detailed descriptions of status epilepticus and, for the first time, the differentiation of “status epilepticus” as a distinct entity from the rest of epilepsy. At this time, it was also realized that inducing “sedation,” often to the level of anesthesia, was the best approach to the treatment of status epilepticus, and this is still a predominant assumption. The antiepileptics used included bromide given orally, hypodermally, rectally, or even by direct injection into the stomach, as well as amyl nitrate, apomorphine, atropine, chloral, chloroform, ether, hyoscine, morphia, opium, quinine, strophanthus, and valerian. It is interesting to note that most of these drugs are γ-aminobutyric acid (GABA)ergic in action, and GABAergic drugs are still today first-line therapies. Gowers, writing in 1881 commented: “In the status epilepticus, and where bromide, even in large does was useless, I have found small hypodermic injections of morphia of great service.” Turner (1907) wrote: “During the height of a status attack nothing will arrest the seizures except the inhalation of chloroform.” Physical therapies were also advocated, including the use of enemata, cerebrospinal fluid (CSF) drainage, cold baths, and venesection. At the turn of the century, there was a strong emphasis on cleansing the bowel, and Shanahan (1915), for instance, stated: “the most urgently indicated procedure in status is a free irrigation of the lower bowel, using gallons of water given at frequent intervals to completely empty the bowel of fecal matter. After the bowel irrigation, choral hydrate or amylene hydrate should be given by enema in sufficient quantity for sedation.” Clark and Prout (1904) gave a very detailed account of their approach to treatment, which included dividing therapy into the prodromal, convulsive, stuporose, and postictal periods, and with different approaches to treatment in each. Theirs was an approach very similar to that employed today, and indeed it is clear that many of the basic principles in the clinical management of status were established by this time.