epi12323-sup-0001-TableS1.docWord document38KTable S1. Degree of orthologous SCN9A amino acid conservation (+) among vertebrates and degree of paralogous amino acid conservation (+) among human sodium alpha channel subunits 1A-12A, for SCN9A variants detected in the present study. Alignments are given for both rare variants and low frequency polymorphisms as defined in the text and in Table 1.
epi12323-sup-0002-TableS2.docWord document62KTable S2. Predicted severity of SCN9A amino acid substitutions was based on their PolyPhen-2 score with alternative assessments from SIFT given in parentheses for comparison.
epi12323-sup-0003-SupplementaryMaterial.docWord document56KAppendix S1. Methods.

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