Critical Review and Invited Commentary
Functional and structural brain networks in epilepsy: What have we learned?
Article first published online: 13 SEP 2013
Wiley Periodicals, Inc. © 2013 International League Against Epilepsy
Volume 54, Issue 11, pages 1855–1865, November 2013
How to Cite
Epilepsia, 54(11):1855–1865, 2013
- Issue published online: 6 NOV 2013
- Article first published online: 13 SEP 2013
- Manuscript Accepted: 28 JUL 2013
- Network analysis;
- Graph theory;
- Functional and structural networks;
- Seizure generation;
Brain functioning is increasingly seen as a complex interplay of dynamic neural systems that rely on the integrity of structural and functional networks. Recent studies that have investigated functional and structural networks in epilepsy have revealed specific disruptions in connectivity and network topology and, consequently, have led to a shift from “focus” to “networks” in modern epilepsy research. Disruptions in these networks may be associated with cognitive and behavioral impairments often seen in patients with chronic epilepsy. In this review, we aim to provide an overview that would introduce the clinical neurologist and epileptologist to this new theoretical paradigm. We focus on the application of a theory, called “network analysis,” to characterize resting-state functional and structural networks and discuss current and future clinical applications of network analysis in patients with epilepsy.