Full-Length Original Research
Increased cortical extracellular adenosine correlates with seizure termination
Version of Record online: 31 JAN 2014
Wiley Periodicals, Inc. © 2014 International League Against Epilepsy
Volume 55, Issue 2, pages 233–244, February 2014
How to Cite
Epilepsia, 55(2):233–244, 2014
- Issue online: 12 FEB 2014
- Version of Record online: 31 JAN 2014
- Manuscript Accepted: 14 NOV 2013
- National Institutes of Health. Grant Numbers: K08 NS 52252, R01 NS 70872, R01 NS 74013
- Mayo Foundation. Grant Number: R01 NS063039-01
- Epilepsy Foundation
- NCRR CTSA. Grant Number: UL1 RR024150
Vol. 55, Issue 9, 1475, Version of Record online: 14 AUG 2014
Data S1. Methods.
Figure S1. (A) In vitro flow cell analysis of 5 μm of relative analyte, that is, adenosine (ADO), ATP, hypoxanthine (HX), and so on, represented by folded voltammograms. All analytes were analyzed with a triangular waveform FSCV from −0.4 to 1.5. Note most purinomic compounds are unique with this electrochemical analysis. However, HX and ADO are very similar with the exception of the lack of the 1.0 V peak. (B) Although purine nucleic acid components appear similar (adenosine and guanosine) in unfolded voltammograms, they are dissimilar when unfolded and are easily resolved.
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