Research in the pre-paradigmatic, applied scientific field of entrepreneurship is characterized mainly as exploratory. This article advocates for a considerable shift toward a more effective applied research agenda. An applied research program is proposed based on modifications to a Lakatosian research program. The agenda extends beyond typical calls for more replication work to include a focus on practical outcomes, practical significance, and surprising findings among other things. The intent is to produce substantially more practical knowledge—knowledge that is useful to entrepreneurs, policy makers, educators, and scholars.