Contemporary pulp revascularization procedures have been successful in achieving endodontic infection control and promoting the root mineralization process. However, there is still no agreement on the methods to produce predictable clinical outcomes or optimal disinfection protocols. Furthermore, there is no evidence for actual pulp regeneration in humans or in in situ animal models. This review will outline the various factors involved in undertaking this procedure, with a special emphasis on the antimicrobial strategies employed and the available information on their efficacy. Areas in which information is lacking and research is needed will also be presented.