Endodontic management of immature permanent teeth with necrotic pulps is both a clinical problem for dental practitioners and a public health care problem. Although it is feasible to perform apexification procedures, the long-term survival of these teeth is questionable due to thin, incompletely formed dentinal walls. Regenerative endodontic procedures have emerged as a viable treatment alternative for these teeth. This review summarizes the evolution of these procedures while presenting recent advances, including treatment protocol modifications based on translational studies and future bioengineering approaches.