Association mapping of genetic risk factors for chronic wasting disease in wild deer
Article first published online: 30 AUG 2012
© 2012 The Authors. Evolutionary Applications published by Blackwell Publishing Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Volume 6, Issue 2, pages 340–352, February 2013
How to Cite
Matsumoto, T., Samuel, M. D., Bollinger, T., Pybus, M. and Coltman, D. W. (2013), Association mapping of genetic risk factors for chronic wasting disease in wild deer. Evolutionary Applications, 6: 340–352. doi: 10.1111/eva.12003
- Issue published online: 18 FEB 2013
- Article first published online: 30 AUG 2012
- Manuscript Accepted: 11 JUL 2012
- Manuscript Received: 22 NOV 2011
- chronic wasting disease;
- genetic risk factor;
- linkage disequilibrium;
- microsatellite markers;
- mule deer;
- NF1 ;
- PRNP ;
- white-tailed deer
Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy affecting North American cervids. We assessed the feasibility of association mapping CWD genetic risk factors in wild white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) using a panel of bovine microsatellite markers from three homologous deer linkage groups predicted to contain candidate genes. These markers had a low cross-species amplification rate (27.9%) and showed weak linkage disequilibrium (<1 cM). Markers near the prion protein and the neurofibromin 1 (NF1) genes were suggestively associated with CWD status in white-tailed deer (P = 0.006) and mule deer (P = 0.02), respectively. This is the first time an association between the NF1 region and CWD has been reported.