The real war on cancer: the evolutionary dynamics of cancer suppression
Article first published online: 10 OCT 2012
© 2012 The Authors. Evolutionary Applications published by Blackwell Publishing Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Special Issue: Evolution and Cancer
Volume 6, Issue 1, pages 11–19, January 2013
How to Cite
Nunney, L. (2013), The real war on cancer: the evolutionary dynamics of cancer suppression. Evolutionary Applications, 6: 11–19. doi: 10.1111/eva.12018
- Issue published online: 21 JAN 2013
- Article first published online: 10 OCT 2012
- Manuscript Accepted: 7 SEP 2012
- Manuscript Received: 23 JUN 2012
- 1990. International differences in body height and weight and their relationship to cancer incidence. Nutrition and Cancer 14:69–77. , and .
- 1988. Are cell number and cell proliferation risk factors for cancer? Journal of the National Cancer Institute 80:772–775. , and .
- 1988. Adult stature and risk of cancer. Cancer Research 48:1658–1662. , , , , and .
- 1954. The age distribution of cancer and a multistage theory of carcinogenesis. British Journal of Cancer 8:1–12. , and .
- 2007. Genetic progression and the waiting time to cancer. PLoS Computational Biology 3: e225 (8pp). , , , , , , et al.
- Collaborative Group on Epidemiological Studies of Ovarian Cancer. 2012. Ovarian cancer and body size: individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies. PLoS Medicine 9: e1001200 (11pp).
- 2002. AIDS-related malignancies. Nature Reviews Cancer 2:373–382. , and .
- 1997. Sunlight and the onset of skin cancer. Trends in Genetics 13:410–414.
- 1975. Mutation selection and the natural history of cancer. Nature 255:197–200. .
- 2010. A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates. BMC Cancer 10:1–12. , and .
- 2011. Peto's Paradox: evolution's prescription for cancer prevention. Trends in Ecology and Evolution 26:175–182. , and .
- 2005. Evolutionary biology of cancer. Trends in Ecology and Evolution 20:545–552. , and .
- 2011. Evolved tumor suppression: why are we so good at not getting cancer? Cancer Research 71:3739–3744. .
- 2000. The age of cancer. Nature 408:248–254.
- 2010. Walls around tumours — why plants do not develop cancer. Nature Reviews Cancer 10:794–802. , and .
- 2011. Mortality in North American dogs from 1984 to 2004: an investigation into age-, size-, and breed-related causes of death. Journal of Veterinary Internal Medicine 25:187–198. , , and .
- 2007. Do Large Dogs Die Young? Journal of Experimental Zoology (Mol Dev Evol) 308B:119–126. , , , , and .
- 2007. Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Research 35:7406–7416. , , and .
- 2009. Is cancer a genetic program with an unknown function? Medical Hypotheses 72:407–408. .
- 2007. Darwinian medicine: a case for cancer. Nature Reviews Cancer 7:213–221. .
- 2011. Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk. Lancet Oncology 12:785–794. , , , , , ; Million Women Study collaborators.
- 2007. Statistical analysis regarding the effects of height and weight on life span of the domestic dog. Research in Veterinary Science 82:208–214. , , and .
- 1964. The genetical evolution of social behavior. I and II.. Journal of Theoretical Biology 7:1–52.
- 1978. Model for the incidence of embryonal cancers: Application to retinoblastoma. Proceedings of the National Academy of Sciences 75:2453–2457. , and .
- 2007. Scaling of human body composition to stature: new insights into body mass index. American Journal of Clinical Nutrition 86:82–91. , , , , and .
- 2010. Adult body size, hormone receptor status, and premenopausal breast cancer risk in a multiethnic population. The San Francisco Bay Area Breast Cancer Study. American Journal of Epidemiology 173:201–216. , , , , and .
- 1997. Gatekeepers and caretakers. Nature 386:761–763. , and .
- 1971. Mutation and cancer: statistical study of retinoblastoma. Proceedings of the National Academy of Sciences 68:820–823. .
- 2003. Cancer selection. Nature Reviews Cancer 3:226–231. , , and .
- 2010. A systematic review and meta-analysis of the relationship between body size and testicular cancer. British Journal of Cancer 103:1467–1474. , , and .
- 2002. Multistage carcinogenesis and the incidence of colorectal cancer. Proceedings of the National Academy of Sciences 99:15095–15100. , and .
- 2009. The first 30 years of p53: growing ever more complex. Nature Reviews Cancer 9:749–758. , and .
- 2005. On evolutionary origin of cancer. Cancer Cell International 5: 5 (9pp). .
- 2011. Mechanisms Limiting Body Growth in Mammals. Endocrine Reviews 32:422–440. , and .
- 1964. Group selection and kin selection. Nature 201:1145–1147. .
- 1995. The Major Transitions in Evolution. Freeman, Oxford. , and .
- 2006. Cancer as an evolutionary and ecological process. Nature Reviews Cancer 6:924–935. , , , and .
- 1999. Longevity of British breeds of dog, and its relationships with sex, size, cardiovascular variables and disease. Veterinary Record 145:625–629. .
- 1996. Cooperation and conflict in the evolution of individuality. II. Conflict mediation. Proceedings of the Royal Society B: Biological Sciences 263:813–822. .
- 1999. Darwinian Dynamics, Evolutionary Transitions in Fitness and Individuality. Princeton University Press, Princeton, NJ. .
- 1953. A new theory on the cancer-inducing mechanism. British Journal of Cancer 7:68–72. .
- 1999a. Lineage selection and the evolution of multistep carcinogenesis. Proceedings of the Royal Society B: Biological Sciences 266:493–498. .
- 1999b. Lineage selection: natural selection for long-term benefit. In L. Keller ed. Levels of Selection in Evolution, pp. 238–252. Princeton University Press, Princeton. .
- 2003. The population genetics of multistage carcinogenesis. Proceedings of the Royal Society B: Biological Sciences 270:1183–1191. .
- 1977. Epidemiology, multistage models, and short-term mutagenicity tests. In H. H. Hiatt, J. D. Watson, and J. A. Winsten, eds. The Origins of Human Cancer, pp. 1403–1428. (Cold Spring Harbor Conferences on Cell Proliferation, vol. 4, Cold Spring Harbor Laboratory, NY). .
- 1996. Size Control: The Regulation of Cell Numbers in Animal Development. Cell 86:173–175.
- 2003. Comparative biology of mouse versus human cells: modelling human cancer in mice. Nature Reviews Cancer 3:952–959. , and .
- 2004. Species- and cell type-specific requirements for cellular transformation. Cancer Cell 6:171–183. , , , and .
- 2012. Cellular epigenetic stability and cancer. Trends in Genetics 28:118–127. , and .
- 2007. Telomerase activity coevolves with body mass not lifespan. Aging Cell 6:45–52. , , , , , , et al.
- 2008. Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell 7:813–823. , , , , , , et al.
- 2009. Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proceedings of the National Academy of Sciences 106:19352–19357. , , , , , , et al.
- 1999. The onset and extent of genomic instability in sporadic colorectal tumor progression. Proceedings of the National Academy of Sciences 96:15121–15126. , , , , , , and
- 1966. Canine bone sarcoma: Estimation of relative risk as a function of body size. Journal of the National Cancer Institute 36:1137–1150.
- 2004 Multistage carcinogenesis. British Journal of Cancer 91:1981–1982. .
- 1991. Comparative aspects of osteosarcoma. Dog versus man. Clinical Orthopedics and Related Research 270:159–168. , , , and .