Modelling the evolution of genetic instability during tumour progression
Article first published online: 26 NOV 2012
© 2012 The Authors. Evolutionary Applications published by Blackwell Publishing Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Special Issue: Evolution and Cancer
Volume 6, Issue 1, pages 20–33, January 2013
How to Cite
S. Datta, R., Gutteridge, A., Swanton, C., Maley, C. C. and Graham, T. A. (2013), Modelling the evolution of genetic instability during tumour progression. Evolutionary Applications, 6: 20–33. doi: 10.1111/eva.12024
- Issue published online: 21 JAN 2013
- Article first published online: 26 NOV 2012
- Manuscript Accepted: 28 SEP 2012
- Manuscript Received: 5 SEP 2012
|eva12024-sup-0001-FigS1.pdf||application/PDF||6K||Figure S1. Housekeeper mutations and an evolving mutation rate with moderate to strong selection.|
|eva12024-sup-0002-FigS2.pdf||application/PDF||6K||Figure S2. Requiring different numbers of driver mutations for cancer.|
|eva12024-sup-0003-FigS3.pdf||application/PDF||15K||Figure S3. Abundant deleterious mutations and the evolution of an increased mutation rate.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.