Geographic population structure of the African malaria vector Anopheles gambiae suggests a role for the forest-savannah biome transition as a barrier to gene flow
Article first published online: 10 JUN 2013
© 2013 The Authors. Published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 6, Issue 6, pages 910–924, September 2013
How to Cite
J, P., A, E.-Y., JL, V., B, G., F, S., M, M., JD, C., F, S., N, E., D, W., MJ, D., A, C. and A, d. T. (2013), Geographic population structure of the African malaria vector Anopheles gambiae suggests a role for the forest-savannah biome transition as a barrier to gene flow. Evolutionary Applications, 6: 910–924. doi: 10.1111/eva.12075
- Issue published online: 27 AUG 2013
- Article first published online: 10 JUN 2013
- Manuscript Accepted: 29 APR 2013
- Manuscript Received: 28 AUG 2012
- UNICEF/UNDP/World Bank/WHO Special Programme for Research
- Training in Tropical Diseases. Grant Number: A50239
- Fundação para a Ciência e Tecnologia/MCTES/FEDER Portugal. Grant Number: SFRH/BD/36410/2007
- Anopheles gambiae ;
- geographic regions;
- molecular forms;
- population structure
The primary Afrotropical malaria mosquito vector Anopheles gambiae sensu stricto has a complex population structure. In west Africa, this species is split into two molecular forms and displays local and regional variation in chromosomal arrangements and behaviors. To investigate patterns of macrogeographic population substructure, 25 An. gambiae samples from 12 African countries were genotyped at 13 microsatellite loci. This analysis detected the presence of additional population structuring, with the M-form being subdivided into distinct west, central, and southern African genetic clusters. These clusters are coincident with the central African rainforest belt and northern and southern savannah biomes, which suggests restrictions to gene flow associated with the transition between these biomes. By contrast, geographically patterned population substructure appears much weaker within the S-form.