EXPERIMENTAL RESEARCH STUDIES
Further characterisation of an experimental model of tendinopathy in the horse
Article first published online: 28 FEB 2013
© 2012 EVJ Ltd
Equine Veterinary Journal
Volume 45, Issue 5, pages 642–648, September 2013
How to Cite
Cadby, J. A., David, F., van de Lest, C., Bosch, G., van Weeren, P. R., Snedeker, J. G. and van Schie, H. T. M. (2013), Further characterisation of an experimental model of tendinopathy in the horse. Equine Veterinary Journal, 45: 642–648. doi: 10.1111/evj.12035
- Issue published online: 2 AUG 2013
- Article first published online: 28 FEB 2013
- Accepted manuscript online: 20 DEC 2012 10:30AM EST
- Manuscript Accepted: 2 DEC 2012
- Manuscript Received: 5 DEC 2011
- experimental model;
- surgical lesion;
- energy-storing tendon;
Reasons for performing study
Injuries in energy-storing tendons are common in both horses and man. The high prevalence of reinjury and the relatively poor prognosis for returning to preinjury performance levels warrant further research, for which well characterised models would be very helpful.
Given the clinical similarities in tendinopathy of energy-storing tendons, we hypothesised that a recently developed experimental model of equine tendon injury would display many of the characteristics of clinical tendinopathy and could therefore be of use for both species, thus providing comparative insight to the human condition and offering direct potential impact to equine medicine.
In vivo experimental study.
Surgical lesions were created in the superficial digital flexor tendon (SDFT) of 6 horses. Clinical examination, as well as biochemistry, histology and immunohistochemistry were performed on the harvested samples at 6 weeks post surgery.
Disrupted collagen fibres, increased glycosaminoglycan content, increased presence of tenocytes with plump nuclei, the scarcity of inflammatory cells, increased matrix metalloproteinase (MMP) activity and neovascularisation were observed and found to be consistent with clinical tendinopathy.
Conclusion and relevance
This model displays the key features of the most common human and equine degenerative tendon disorders and is therefore an appropriate, if still imperfect, model of tendinopathy.