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Serial plasma vasopressin concentration in healthy and hospitalised neonatal foals

Authors


Summary

Reasons for performing study

Vasopressin dysregulation occurs in critically ill human patients and in neonatal foals. Limited data about serial plasma vasopressin dynamics exist in sick neonatal foals.

Objectives

To evaluate serial plasma arginine vasopressin (AVP) concentrations in sick neonatal foals.

Study design

Prospective, longitudinal clinical study.

Methods

Plasma samples were collected from 7 healthy and 26 sick foals before and after initial fluid resuscitation and 12, 24, 36, 48 and 96 h after presentation. Foals with a modified sepsis score ≥11 were considered septic.

Results

Admission AVP was increased in septic foals compared to healthy and to sick, nonseptic foals. There were no significant differences between groups on subsequent days. Nonsurvivors had higher AVP concentrations than survivors.

Conclusions

Plasma AVP concentrations are higher in septic foals on admission than in healthy and sick nonseptic foals. Higher early plasma AVP concentrations are associated with increased mortality.

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