ANALYTICAL CLINICAL STUDIES
Polymorphisms in TNC and COL5A1 genes are associated with risk of superficial digital flexor tendinopathy in National Hunt Thoroughbred racehorses
Article first published online: 16 SEP 2013
© 2013 EVJ Ltd
Equine Veterinary Journal
Volume 46, Issue 3, pages 289–293, May 2014
How to Cite
Tully, L. J., Murphy, A. M., Smith, R. K. W., Hulin-Curtis, S. L., Verheyen, K. L. P. and Price, J. S. (2014), Polymorphisms in TNC and COL5A1 genes are associated with risk of superficial digital flexor tendinopathy in National Hunt Thoroughbred racehorses. Equine Veterinary Journal, 46: 289–293. doi: 10.1111/evj.12134
- Issue published online: 10 APR 2014
- Article first published online: 16 SEP 2013
- Accepted manuscript online: 3 JUL 2013 05:27AM EST
- Manuscript Accepted: 27 JUN 2013
- Manuscript Received: 6 MAR 2013
- Horserace Betting Levy Board Research Scholarship
Supporting Information Item S1: Gene identifier and gene position EquCab 2.0 reference, single nucleotide polymorphism reference, NCBI position, alleles and minor allele frequency for superficial digital flexor tendinopathy disease association study.
Supporting Information Item S2: Schematic diagram to illustrate predicted exon structure and position of single nucleotide polymorphisms in the TNC, FMOD, MMP3 and MMP13 genes (top to bottom panels respectively).
Supporting Information Item S3: Schematic diagram to illustrate predicted exon structure and position of single nucleotide polymorphisms in the COL5A1, COMP and COL1A1 genes (top to bottom panels respectively).
Supporting Information Item S4: Polymerase chain reaction primers used to resequence single nucleotide polymorphisms in 6 National Hunt Thoroughbreds. Single nucleotide polymorphisms indicated with * were not optimised. Annealing temperature was 58°C for all primers.
Supporting Information Item S5: Allele-specific primers used for SNaPshot™ assays. Single nucleotide polymorphisms are denoted in red type face.
Supporting Information Item S6: Univariable conditional logistic regression results of genotype associations and SDF tendinopathy.
Supporting Information Item S7: Linkage disequilibrium (LD) measure between TNC, COL1A1, COL5A1, MMP3, MMP13, FMOD and COMP single nucleotide polymorphisms.
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