INTERGENERATIONAL PHENOTYPIC MIXING IN VIRAL EVOLUTION
Article first published online: 4 FEB 2013
© 2013 The Author(s). Evolution © 2013 The Society for the Study of Evolution.
Volume 67, Issue 6, pages 1815–1822, June 2013
How to Cite
Loverdo, C. and Lloyd-Smith, J. O. (2013), INTERGENERATIONAL PHENOTYPIC MIXING IN VIRAL EVOLUTION. Evolution, 67: 1815–1822. doi: 10.1111/evo.12048
- Issue published online: 4 JUN 2013
- Article first published online: 4 FEB 2013
- Accepted manuscript online: 10 JAN 2013 05:58AM EST
- Manuscript Accepted: 25 DEC 2012
- Manuscript Received: 8 JUL 2012
- National Science Foundation (NSF). Grant Number: EF-0928690
Viral particles (virions) are made of genomic material packaged with proteins, drawn from the pool of proteins in the parent cell. It is well known that when virion concentrations are high, cells can be coinfected with multiple viral strains that can complement each other. Viral genomes can then interact with proteins derived from different strains, in a phenomenon known as phenotypic mixing. But phenotypic mixing is actually far more common: viruses mutate very often, and each time a mutation occurs, the parent cell contains different types of viral genomes. Due to phenotypic mixing, changes in viral phenotypes can be shifted by a generation from the mutations that cause them. In the regime of evolutionary invasion and escape, when mutations are crucial for the virus to survive, this timing can have a large influence on the probability of emergence of an adapted strain. Modeling the dynamics of viral evolution in these contexts thus requires attention to the mutational mechanism and the determinants of fitness.