METABOLIC FLUX IS A DETERMINANT OF THE EVOLUTIONARY RATES OF ENZYME-ENCODING GENES
Version of Record online: 19 SEP 2013
© 2013 The Author(s). Evolution © 2013 The Society for the Study of Evolution.
Volume 68, Issue 2, pages 605–613, February 2014
How to Cite
Colombo, M., Laayouni, H., Invergo, B. M., Bertranpetit, J. and Montanucci, L. (2014), METABOLIC FLUX IS A DETERMINANT OF THE EVOLUTIONARY RATES OF ENZYME-ENCODING GENES. Evolution, 68: 605–613. doi: 10.1111/evo.12262
- Issue online: 28 JAN 2014
- Version of Record online: 19 SEP 2013
- Accepted manuscript online: 29 AUG 2013 09:34AM EST
- Manuscript Accepted: 15 AUG 2013
- Manuscript Received: 27 FEB 2013
- Juan de la Cierva Program of the Spanish Ministry of Science and Innovation (MICINN). Grant Number: BFU2010-19443
- Direcció General de Recerca, Generalitat de Catalunya
Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
Table S1. List of the 30 enzymatic reactions of the pathway along with their enzyme classification (EC) numbers.
Table S2. List of the 18 nonenzymatic reactions excluded from the evolutionary analysis.
Table S3. Results for the likelihood ratio test of positive selection.
Figure S1. Substrate graph of the erythrocyte core metabolic network.
Figure S2. Scatter-plots of the evolutionary rates (dN/dS, dN, dS) versus centrality measures.
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