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Table S1. List of the 30 enzymatic reactions of the pathway along with their enzyme classification (EC) numbers.

Table S2. List of the 18 nonenzymatic reactions excluded from the evolutionary analysis.

Table S3. Results for the likelihood ratio test of positive selection.

Figure S1. Substrate graph of the erythrocyte core metabolic network.

Figure S2. Scatter-plots of the evolutionary rates (dN/dS, dN, dS) versus centrality measures.

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