SENSITIVITY OF THE DISTRIBUTION OF MUTATIONAL FITNESS EFFECTS TO ENVIRONMENT, GENETIC BACKGROUND, AND ADAPTEDNESS: A CASE STUDY WITH DROSOPHILA
Article first published online: 6 DEC 2013
© 2013 The Author(s). Evolution © 2013 The Society for the Study of Evolution.
Volume 68, Issue 3, pages 840–853, March 2014
How to Cite
Wang, A. D., Sharp, N. P. and Agrawal, A. F. (2014), SENSITIVITY OF THE DISTRIBUTION OF MUTATIONAL FITNESS EFFECTS TO ENVIRONMENT, GENETIC BACKGROUND, AND ADAPTEDNESS: A CASE STUDY WITH DROSOPHILA. Evolution, 68: 840–853. doi: 10.1111/evo.12309
- Issue published online: 3 MAR 2014
- Article first published online: 6 DEC 2013
- Accepted manuscript online: 11 NOV 2013 02:55AM EST
- Manuscript Accepted: 22 OCT 2013
- Manuscript Received: 3 MAY 2013
- Natural Sciences and Engineering Research Council of Canada
- Distribution of fitness effects;
Heterogeneity in the fitness effects of individual mutations has been found across different environmental and genetic contexts. Going beyond effects on individual mutations, how is the distribution of selective effects, f(s), altered by changes in genetic and environmental context? In this study, we examined changes in the major features of f(s) by estimating viability selection on 36 individual mutations in Drosophila melanogaster across two different environments in two different genetic backgrounds that were either adapted or nonadapted to the two test environments. Both environment and genetic background affected selection on individual mutations. However, the overall distribution f(s) appeared robust to changes in genetic background but both the mean, E(s), and the variance, V(s) were dependent on the environment. Between these two properties, V(s) was more sensitive to environmental change. Contrary to predictions of fitness landscape theory, the match between genetic background and assay environment (i.e., adaptedness) had little effect on f(s).