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Fig. S1. Alignment of Thr3 from Streptomyces sp. OH-5093 with Fe(II) nonheme α-ketoglutarate-dependent halogenases.

Fig. S2. Alignment of Orf1 (hypothetical) from Streptomyces sp. OH-5093 with most similar tRNA editing domains whose 3D structures are known.

Fig. S3. Homology model of Thr3 from the Streptomyces sp. OH-5093 active site superimposed on the curacin halogenase active site from Lyngbya majuscula.

Fig. S4. Alignment of Thr2 from Streptomyces sp. OH-5093 with SyrB1-T (residues 523–614 of SyrB1) from P. s. pv. syringae B301DR.

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