• 1
    Ribrault C, Sekimoto K & Triller A (2011) From the stochasticity of molecular processes to the variability of synaptic transmission. Nat Rev Neurosci 12, 375387.
  • 2
    Haizlip KM & Janssen PM (2011) In vitro studies of early cardiac remodeling: impact on contraction and calcium handling. Front Biosci 3, 10471057.
  • 3
    White KL, Pate BJ & Sessions BR (2010) Oolemma receptors and oocyte activation. Syst Biol Reprod Med 56, 365375.
  • 4
    Leclerc E & Heizmann CW (2011) The importance of Ca2+/Zn2+ signaling S100 proteins and RAGE in translational medicine. Front Biosci 3, 12321262.
  • 5
    Rohde D, Brinks H, Ritterhoff J, Qui G, Ren S & Most P (2011) S100A1 gene therapy for heart failure: a novel strategy on the verge of clinical trials. J Mol Cell Cardiol 50, 777784.
  • 6
    Wolf S, Haase-Kohn C & Pietzsch J (2011) S100A2 in cancerogenesis: a friend or a foe? Amino Acids 41, 849861.
  • 7
    Gebhardt C, Nemeth J, Angel P & Hess J (2006) S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol 72, 16221631.
  • 8
    Pietzsch J & Hoppmann S (2009) Human S100A12: a novel key player in inflammation? Amino Acids 36, 381389.
  • 9
    Heizmann CW, Ackermann GE & Galichet A (2007) Pathologies involving the S100 proteins and RAGE. Subcell Biochem 45, 93138.
  • 10
    Calabretta B, Battini R, Kaczmarek L, de Riel JK & Baserga R (1986) Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein. J Biol Chem 261, 1262812632.
  • 11
    Vimalachandran D, Greenhalf W, Thompson C, Luttges J, Prime W, Campbell F, Dodson A, Watson R, Crnogorac-Jurcevic T, Lemoine N et al. (2005) High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients. Cancer Res 65, 32183225.
  • 12
    Komatsu K, Murata K, Kameyama M, Ayaki M, Mukai M, Ishiguro S, Miyoshi J, Tatsuta M, Inoue M & Nakamura H (2002) Expression of S100A6 and S100A4 in matched samples of human colorectal mucosa, primary colorectal adenocarcinomas and liver metastases. Oncology 63, 192200.
  • 13
    Kim J, Yoon S, Joo J, Lee Y, Lee K, Chung J & Choe I (2002) S100A6 protein as a marker for differential diagnosis of cholangiocarcinoma from hepatocellular carcinoma. Hepatol Res 23, 274286.
  • 14
    Breen EC & Tang K (2003) Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro. J Cell Biochem 88, 848854.
  • 15
    De Petris L, Orre LM, Kanter L, Pernemalm M, Koyi H, Lewensohn R & Lehtio J (2009) Tumor expression of S100A6 correlates with survival of patients with stage I non-small-cell lung cancer. Lung Cancer 63, 410417.
  • 16
    Wang XH, Zhang LH, Zhong XY, Xing XF, Liu YQ, Niu ZJ, Peng Y, Du H, Zhang GG, Hu Y et al. (2010) S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer. Am J Pathol 177, 586597.
  • 17
    Schneider G, Nieznanski K, Kilanczyk E, Bieganowski P, Kuznicki J & Filipek A (2007) CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies. Biochim Biophys Acta 1773, 16281636.
  • 18
    Berta GN, Ghezzo F, D'Avolio A, Zulian P, Carbone V, Racca S, Vercellino V & Di Carlo F (1997) Enhancement of calcyclin gene RNA expression in squamous cell carcinoma of the oral mucosa, but not in benign lesions. J Oral Pathol Med 26, 206210.
  • 19
    Murphy LC, Murphy LJ, Tsuyuki D, Duckworth ML & Shiu RP (1988) Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum. J Biol Chem 263, 23972401.
  • 20
    McKiernan E, McDermott EW, Evoy D, Crown J & Duffy MJ (2011) The role of S100 genes in breast cancer progression. Tumour Biol 32, 441450.
  • 21
    Lorenz S, Eszlinger M, Paschke R, Aust G, Weick M, Fuhrer D & Krohn K (2010) Calcium signaling of thyrocytes is modulated by TSH through calcium binding protein expression. Biochim Biophys Acta 1803, 352360.
  • 22
    Komatsu K, Kobune-Fujiwara Y, Andoh A, Ishiguro S, Hunai H, Suzuki N, Kameyama M, Murata K, Miyoshi J, Akedo H et al. (2000) Increased expression of S100A6 at the invading fronts of the primary lesion and liver metastasis in patients with colorectal adenocarcinoma. Br J Cancer 83, 769774.
  • 23
    Filipek A, Michowski W & Kuznicki J (2008) Involvement of S100A6 (calcyclin) and its binding partners in intracellular signaling pathways. Adv Enzyme Regul 48, 225239.
  • 24
    Madureira PA, Surette AP, Phipps KD, Taboski MA, Miller VA & Waisman DM (2011) The role of the annexin A2 heterotetramer in vascular fibrinolysis. Blood 118, 47894797.
  • 25
    Li C, Zhang F & Wang Y (2010) S100A proteins in the pathogenesis of experimental corneal neovascularization. Mol Vis 16, 22252235.
  • 26
    Hsieh HL, Schafer BW, Cox JA & Heizmann CW (2002) S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells. J Cell Sci 115, 31493158.
  • 27
    Ishii A, Suzuki M, Satomi K, Kobayashi H, Sakashita S, Kano J, Pei Y, Minami Y, Ishikawa S & Noguchi M (2009) Increased cytoplasmic S100A6 expression is associated with pulmonary adenocarcinoma progression. Pathol Int 59, 623630.
  • 28
    Hirschhorn RR, Aller P, Yuan ZA, Gibson CW & Baserga R (1984) Cell-cycle-specific cDNAs from mammalian cells temperature sensitive for growth. Proc Natl Acad Sci USA 81, 60046008.
  • 29
    Ide T, Ninomiya-Tsuji J, Ferrari S, Philiponis V & Baserga R (1986) Expression of growth-regulated genes in tsJT60 cells, a temperature-sensitive mutant of the cell cycle. Biochemistry 25, 70417046.
  • 30
    Lindqvist A, Rodriguez-Bravo V & Medema RH (2009) The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J Cell Biol 185, 193202.
  • 31
    Harris SL & Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24, 28992908.
  • 32
    Itahana K, Campisi J & Dimri GP (2007) Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol 371, 2131.
  • 33
    Slomnicki LP & Lesniak W (2010) S100A6 (calcyclin) deficiency induces senescence-like changes in cell cycle, morphology and functional characteristics of mouse NIH 3T3 fibroblasts. J Cell Biochem 109, 576584.
  • 34
    Riabowol K, Draetta G, Brizuela L, Vandre D & Beach D (1989) The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57, 393401.
  • 35
    Lesniak W, Slomnicki LP & Kuznicki J (2007) Epigenetic control of the S100A6 (calcyclin) gene expression. J Invest Dermatol 127, 23072314.
  • 36
    Lesniak W (2011) Epigenetic regulation of S100 protein expression. Clin Epigenetics 2, 7783.
  • 37
    Slomnicki LP, Nawrot B & Lesniak W (2009) S100A6 binds p53 and affects its activity. Int J Biochem Cell Biol 41, 784790.
  • 38
    Shimamoto S, Takata M, Tokuda M, Oohira F, Tokumitsu H & Kobayashi R (2008) Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain. J Biol Chem 283, 2824628258.
  • 39
    Pratt WB, Galigniana MD, Harrell JM & DeFranco DB (2004) Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement. Cell Signal 16, 857872.
  • 40
    Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King FW, Helwak A, Boros J, Zylicz A & Zylicz M (2004) Hsp90 chaperones wild-type p53 tumor suppressor protein. J Biol Chem 279, 4883648845.
  • 41
    Stingl L, Stuhmer T, Chatterjee M, Jensen MR, Flentje M & Djuzenova CS (2010) Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction. Br J Cancer 102, 157815791.
  • 42
    Filipek A, Gerke V, Weber K & Kuznicki J (1991) Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding proteins obtained by Ca2(+)-dependent affinity chromatography. Eur J Biochem 195, 795800.
  • 43
    Sudo T & Hidaka H (1998) Regulation of calcyclin (S100A6) binding by alternative splicing in the N-terminal regulatory domain of annexin XI isoforms. J Biol Chem 273, 63516357.
  • 44
    Tomas A & Moss SE (2003) Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope. J Biol Chem 278, 2021020216.
  • 45
    Nedjadi T, Kitteringham N, Campbell F, Jenkins RE, Park BK, Navarro P, Ashcroft F, Tepikin A, Neoptolemos JP & Costello E (2009) S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer 101, 11451154.
  • 46
    Drexler HG, Quentmeier H, Dirks WG & MacLeod RA (2002) Bladder carcinoma cell line ECV304 is not a model system for endothelial cells. In Vitro Cell Dev Biol Anim 38, 185186.
  • 47
    Suda K, Rothen-Rutishauser B, Gunthert M & Wunderli-Allenspach H (2001) Phenotypic characterization of human umbilical vein endothelial (ECV304) and urinary carcinoma (T24) cells: endothelial versus epithelial features. In Vitro Cell Dev Biol Anim 37, 505514.
  • 48
    Howell GJ, Herbert SP, Smith JM, Mittar S, Ewan LC, Mohammed M, Hunter AR, Simpson N, Turner AJ, Zachary I et al. (2004) Endothelial cell confluence regulates Weibel-Palade body formation. Mol Membr Biol 21, 413421.
  • 49
    Ewan LC, Jopling HM, Jia H, Mittar S, Bagherzadeh A, Howell GJ, Walker JH, Zachary IC & Ponnambalam S (2006) Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells. Traffic 7, 12701282.
  • 50
    Mittar S, Ulyatt C, Howell GJ, Bruns AF, Zachary IC, Walker JH & Ponnambalam S (2009) VEGFR1 receptor tyrosine kinase localization to the Golgi apparatus is calcium-dependent. Exp Cell Res 315, 877889.
  • 51
    Herbert SP, Odell AF, Ponnambalam S & Walker JH (2007) The confluence-dependent interaction of cytosolic phospholipase A2-alpha with annexin A1 regulates endothelial cell prostaglandin E2 generation. J Biol Chem 282, 3446834478.
  • 52
    Bruns AF, Herbert SP, Odell AF, Jopling HM, Hooper NM, Zachary IC, Walker JH & Ponnambalam S (2010) Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic 11, 161174.
  • 53
    Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, Naldini L & Trono D (1998) Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 72, 98739880.