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Appendix S1. Excel file of Lottia gigantea shell matrix proteomic dataset.

Fig. S1. Comparison of Lottia gigantea SMPs identified in this study or by Mann et al. (2012).

Fig. S2. Phylogenetic analysis of three peroxidase SMPs.

Fig. S3. Reinterpretation of the BMSP-like L. gigantea ORF.

Fig. S4. Comparison of L. gigantea's SMP and various metazoan cyclophilins.

Fig. S5. Alignments of L. gigantea glycosidase SMPs with homologous sequences.

Fig. S6. Alignments of L. gigantea SMPs with putative homologous SMP sequences from bivalve shell matrices.

Fig. S7. Organization of the gene cluster containing LUSP–2 and -3 on L. gigantea genomic scaffold sca_35.

Fig. S8. Alignments of L. gigantea SMPs with putative homologous SMP sequences from Haliotis.

Table S1. Proteomic detection of L. gigantea peroxidase-1 and -2 in various AIM SDS/PAGE bands.

Table S2. Genomic localization of Lottia gigantea SMP genes.

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