• 1
    Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM & Tsai M (2005) Mast cells as ‘tunable’ effector and immunoregulatory cells: recent advances. Annu Rev Immunol 23, 749786.
  • 2
    Raposo G, Marks MS & Cutler DF (2007) Lysosome-related organelles: driving post-Golgi compartments into specialisation. Curr Opin Cell Biol 19, 394401.
  • 3
    Raposo G, Tenza D, Mecheri S, Peronet R, Bonnerot C & Desaymard C (1997) Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. Mol Biol Cell 8, 26312645.
  • 4
    Gilfillan AM & Tkaczyk C (2006) Integrated signalling pathways for mast-cell activation. Nat Rev Immunol 6, 218230.
  • 5
    Föger N, Jenckel A, Orinska Z, Lee K, Chan AC & Bulfone-Paus S (2011) Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b. J Exp Med 208, 17771787.
  • 6
    Frigeri L & Apgar JR (1999) The role of actin microfilaments in the down-regulation of the degranulation response in RBL-2H3 mast cells. J Immunol 162, 22432250.
  • 7
    Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T et al. (2005) Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type Iα. J Exp Med 201, 859870.
  • 8
    Stenmark H (2009) Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10, 513525.
  • 9
    Hutagalung AH & Novick PJ (2011) Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev 91, 119149.
  • 10
    Tolmachova T, Anders R, Stinchcombe J, Bossi G, Griffiths GM, Huxley C & Seabra MC (2004) A general role for Rab27a in secretory cells. Mol Biol Cell 15, 332344.
  • 11
    Gomi H, Mori K, Itohara S & Izumi T (2007) Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane. Mol Biol Cell 18, 43774386.
  • 12
    Fukuda M (2003) Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. J Biol Chem 278, 1539015396.
  • 13
    Tsuboi T & Fukuda M (2006) Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells. J Cell Sci 119, 21962203.
  • 14
    Handley MTW, Haynes LP & Burgoyne RD (2007) Differential dynamics of Rab3A and Rab27A on secretory granules. J Cell Sci 120, 973984.
  • 15
    Herrero-Turrion MJ, Calafat J, Janssen H, Fukuda M & Mollinedo F (2008) Rab27a regulates exocytosis of tertiary and specific granules in human neutrophils. J Immunol 181, 37933803.
  • 16
    Brzezinska AA, Johnson JL, Munafo DB, Crozat K, Beutler B, Kiosses WB, Ellis BA & Catz SD (2008) The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules. Traffic 9, 21512164.
  • 17
    Stinchcombe JC, Barral DC, Mules EH, Booth S, Hume AN, Machesky LM, Seabra MC & Griffiths GM (2001) Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J Cell Biol 152, 825834.
  • 18
    Shirakawa R, Higashi T, Tabuchi A, Yoshioka A, Nishioka H, Fukuda M, Kita T & Horiuchi H (2004) Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. J Biol Chem 279, 1073010737.
  • 19
    Tolmachova T, Abrink M, Futter CE, Authi KS & Seabra MC (2007) Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci USA 104, 58725877.
  • 20
    Johnson JL, Brzezinska AA, Tolmachova T, Munafo DB, Ellis BA, Seabra MC, Hong H & Catz SD (2010) Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic 11, 533547.
  • 21
    Hume AN & Seabra MC (2011) Melanosomes on the move: a model to understand organelle dynamics. Biochem Soc Trans 39, 11911196.
  • 22
    Barral DC, Ramalho JS, Anders R, Hume AN, Knapton HJ, Tolmachova T, Collinson LM, Goulding D, Authi KS & Seabra MC (2002) Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest 110, 247257.
  • 23
    Fukuda M (2005) Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families. J Biochem (Tokyo) 137, 916.
  • 24
    Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP et al. (2010) Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol 12, 1930.
  • 25
    Tuvim MJ, Adachi R, Chocano JF, Moore RH, Lampert RM, Zera E, Romero E, Knoll BJ & Dickey BF (1999) Rab3D, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocytosis. Am J Respir Cell Mol Biol 20, 7989.
  • 26
    Roa M, Paumet F, Le Mao J, David B & Blank U (1997) Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (FcεRI). J Immunol 159, 28152823.
  • 27
    Pombo I, Martin-Verdeaux S, Iannascoli B, Le Mao J, Deriano L, Rivera J & Blank U (2001) IgE receptor type I-dependent regulation of a Rab3D-associated kinase: a possible link in the calcium-dependent assembly of SNARE complexes. J Biol Chem 276, 4289342900.
  • 28
    Riedel D, Antonin W, Fernandez-Chacon R, Alvarez de Toledo G, Jo T, Geppert M, Valentijn JA, Valentijn K, Jamieson JD, Sudhof TC et al. (2002) Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol Cell Biol 22, 64876497.
  • 29
    Goishi K, Mizuno K, Nakanishi H & Sasaki T (2004) Involvement of Rab27 in antigen-induced histamine release from rat basophilic leukemia 2H3 cells. Biochem Biophys Res Commun 324, 294301.
  • 30
    Neeft M, Wieffer M, de Jong AS, Negroiu G, Metz CH, van Loon A, Griffith J, Krijgsveld J, Wulffraat N, Koch H et al. (2005) Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells. Mol Biol Cell 16, 731741.
  • 31
    Elstak ED, Neeft M, Nehme NT, Voortman J, Cheung M, Goodarzifard M, Gerritsen HC, van Bergen En Henegouwen PM, Callebaut I, de Saint Basile G et al. (2011) The munc13-4–rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane. Blood 118, 15701578.
  • 32
    Lambracht-Hall M, Konstantinidou AD & Theoharides TC (1990) Serotonin release from rat brain mast cells in vitro. Neuroscience 39, 199207.
  • 33
    Mizuno K, Tolmachova T, Ushakov DS, Romao M, Abrink M, Ferenczi MA, Raposo G & Seabra MC (2007) Rab27b regulates mast cell granule dynamics and secretion. Traffic 8, 883892.
  • 34
    Koffer A, Tatham PR & Gomperts BD (1990) Changes in the state of actin during the exocytotic reaction of permeabilized rat mast cells. J Cell Biol 111, 919927.
  • 35
    Borovikov YS, Norman JC, Price LS, Weeds A & Koffer A (1995) Secretion from permeabilised mast cells is enhanced by addition of gelsolin: contrasting effects of endogenous gelsolin. J Cell Sci 108, 657666.
  • 36
    Crozat K, Hoebe K, Ugolini S, Hong NA, Janssen E, Rutschmann S, Mudd S, Sovath S, Vivier E & Beutler B (2007) Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med 204, 853863.
  • 37
    Stinchcombe JC, Nomoto H, Cutler DF & Hopkins CR (1995) Anterograde and retrograde traffic between the rough endoplasmic reticulum and the Golgi complex. J Cell Biol 131, 13871401.