Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion
Version of Record online: 2 JAN 2013
© 2012 The Authors Journal compilation © 2012 FEBS
The FEBS Journal
Volume 280, Issue 3, pages 892–903, February 2013
How to Cite
Singh, R. K., Mizuno, K., Wasmeier, C., Wavre-Shapton, S. T., Recchi, C., Catz, S. D., Futter, C., Tolmachova, T., Hume, A. N. and Seabra, M. C. (2013), Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. The FEBS Journal, 280: 892–903. doi: 10.1111/febs.12081
- Issue online: 28 JAN 2013
- Version of Record online: 2 JAN 2013
- Accepted manuscript online: 29 NOV 2012 03:55AM EST
- Manuscript Accepted: 26 NOV 2012
- Manuscript Revised: 31 OCT 2012
- Manuscript Received: 8 OCT 2012
- Wellcome Trust. Grant Number: 075498/Z/04/Z
- UK Medical Research Council
Fig. S1. Surface c-kit and FcεRI expression on wild-type and ashen BMMCs.
Fig. S2. Immunofluorescence analysis of Rab27a and Rab27b localization in BMMCs.
Fig. S3. Immunoblot analysis of Rab27a and Rab27b protein expression in Rab27-deficient BMMCs.
Fig. S4. Analysis of granule size, granule types and granule/plasma membrane distance in wild-type and Rab27-deficient BMMCs.
Fig. S5. Surface c-kit and FcεRI expression on BL/6 and jinx BMMCs.
Table S1. Comparison of secretory responses of wild-type and Rab27-deficient BMMCs to IgE-dependent and -independent stimuli. Values represent P values obtained by statistical comparison (using Student's t test) of secretory responses of wild-type and Rab27-deficient BMMCs using various stimuli where rows and columns intersect.
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