Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion
Article first published online: 2 JAN 2013
© 2012 The Authors Journal compilation © 2012 FEBS
Volume 280, Issue 3, pages 892–903, February 2013
How to Cite
Singh, R. K., Mizuno, K., Wasmeier, C., Wavre-Shapton, S. T., Recchi, C., Catz, S. D., Futter, C., Tolmachova, T., Hume, A. N. and Seabra, M. C. (2013), Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. FEBS Journal, 280: 892–903. doi: 10.1111/febs.12081
- Issue published online: 28 JAN 2013
- Article first published online: 2 JAN 2013
- Accepted manuscript online: 29 NOV 2012 03:55AM EST
- Manuscript Accepted: 26 NOV 2012
- Manuscript Revised: 31 OCT 2012
- Manuscript Received: 8 OCT 2012
- Wellcome Trust. Grant Number: 075498/Z/04/Z
- UK Medical Research Council
Fig. S1. Surface c-kit and FcεRI expression on wild-type and ashen BMMCs.
Fig. S2. Immunofluorescence analysis of Rab27a and Rab27b localization in BMMCs.
Fig. S3. Immunoblot analysis of Rab27a and Rab27b protein expression in Rab27-deficient BMMCs.
Fig. S4. Analysis of granule size, granule types and granule/plasma membrane distance in wild-type and Rab27-deficient BMMCs.
Fig. S5. Surface c-kit and FcεRI expression on BL/6 and jinx BMMCs.
Table S1. Comparison of secretory responses of wild-type and Rab27-deficient BMMCs to IgE-dependent and -independent stimuli. Values represent P values obtained by statistical comparison (using Student's t test) of secretory responses of wild-type and Rab27-deficient BMMCs using various stimuli where rows and columns intersect.
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.