l-Serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the developing central nervous system
Article first published online: 24 FEB 2013
© 2013 The Authors Journal compilation © 2013 FEBS
Volume 280, Issue 6, pages 1502–1517, March 2013
How to Cite
Sayano, T., Kawakami, Y., Kusada, W., Suzuki, T., Kawano, Y., Watanabe, A., Takashima, K., Arimoto, Y., Esaki, K., Wada, A., Yoshizawa, F., Watanabe, M., Okamoto, M., Hirabayashi, Y. and Furuya, S. (2013), l-Serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the developing central nervous system. FEBS Journal, 280: 1502–1517. doi: 10.1111/febs.12146
- Issue published online: 12 MAR 2013
- Article first published online: 24 FEB 2013
- Accepted manuscript online: 25 JAN 2013 12:50PM EST
- Manuscript Accepted: 21 JAN 2013
- Manuscript Revised: 9 JAN 2013
- Manuscript Received: 16 AUG 2012
- KAKENHI Grants-in-Aid for Scientific Research Areas. Grant Numbers: 20248014, 22380078
Fig. S1. Phosphorylation of eIF2α protein in the brain of Phgdh KO and WT embryos.
Fig. S2. Phosphorylation of eIF2α protein in KO-MEFs under l-Ser-deprived conditions.
Fig. S3. Expression of Gadd34/Ppp1r15a in KO-MEFs and Phgdh KO brains.
Fig. S4. Expression of Chop/Ddit3 in KO-MEFs and Phgdh KO brains.
Fig. S5. Eif4ebp1 mRNA induction in the hippocampus of brain-specific Phgdh KO mice.
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