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Fig. S1. Phosphorylation of eIF2α protein in the brain of Phgdh KO and WT embryos.

Fig. S2. Phosphorylation of eIF2α protein in KO-MEFs under l-Ser-deprived conditions.

Fig. S3. Expression of Gadd34/Ppp1r15a in KO-MEFs and Phgdh KO brains.

Fig. S4. Expression of Chop/Ddit3 in KO-MEFs and Phgdh KO brains.

Fig. S5. Eif4ebp1 mRNA induction in the hippocampus of brain-specific Phgdh KO mice.

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