• 1
    Ross J Jr & Braunwald E (1968) Aortic stenosis. Circulation 38, 6167.
  • 2
    Spinale FG (2002) Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ Res 90, 520530.
  • 3
    Kalogeropoulos AP, Georgiopoulou VV & Butler J (2012) From risk factors to structural heart disease: the role of inflammation. Heart Fail Clin 8, 113123.
  • 4
    Hayashi Y, Call MK, Chikama T, Liu H, Carlson EC, Sun Y, Pearlman E, Funderburgh JL, Babcock G, Liu CY, et al. (2010) Lumican is required for neutrophil extravasation following corneal injury and wound healing. J Cell Sci 123, 29872995.
  • 5
    Wu F & Chakravarti S (2007) Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis. J Immunol 179, 69887000.
  • 6
    Pan S, Chen R, Stevens T, Bronner MP, May D, Tamura Y, McIntosh MW & Brentnall TA (2011) Proteomics portrait of archival lesions of chronic pancreatitis. PLoS One 6, e27574.
  • 7
    Charlton M, Viker K, Krishnan A, Sanderson S, Veldt B, Kaalsbeek AJ, Kendrick M, Thompson G, Que F, Swain J, et al. (2009) Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease. Hepatology 49, 13751384.
  • 8
    Iozzo RV (1997) The family of the small leucine-rich proteoglycans: key regulators of matrix assembly and cellular growth. Crit Rev Biochem Mol Biol 32, 141174.
  • 9
    Kalamajski S & Oldberg A (2009) Homologous sequence in lumican and fibromodulin leucine-rich repeat 5–7 competes for collagen binding. J Biol Chem 284, 534539.
  • 10
    Wæhre A, Halvorsen B, Yndestad A, Husberg C, Sjaastad I, Nygard S, Dahl CP, Ahmed MS, Finsen AV, Reims H, et al. (2011) Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload. PLoS One 6, e18668.
  • 11
    Baba H, Ishiwata T, Takashi E, Xu G & Asano G (2001) Expression and localization of lumican in the ischemic and reperfused rat heart. Jpn Circ J 65, 445450.
  • 12
    Waehre A, Vistnes M, Sjaastad I, Nygard S, Husberg C, Lunde IG, Aukrust P, Yndestad A, Vinge LE, Behmen D, et al. (2012) Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle. J Appl Physiol 112, 13721382.
  • 13
    Moreth K, Iozzo RV & Schaefer L (2012) Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation. Cell Cycle 11, 20842091.
  • 14
    Wu F, Vij N, Roberts L, Lopez-Briones S, Joyce S & Chakravarti S (2007) A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response. J Biol Chem 282, 2640926417.
  • 15
    Smith-Mungo LI & Kagan HM (1998) Lysyl oxidase: properties, regulation and multiple functions in biology. Matrix Biol 16, 387398.
  • 16
    Lopez B, Gonzalez A, Hermida N, Valencia F, de Teresa E & Diez J (2010) Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects. Am J Physiol Heart Circ Physiol 299, H1H9.
  • 17
    Caputo I, Lepretti M, Scarabino C, Esposito C & Proto A (2012) An acetic acid-based extraction method to obtain high quality collagen from archeological bone remains. Anal Biochem 421, 9296.
  • 18
    Schwarze U, Cundy T, Pyott SM, Christiansen HE, Hegde MR, Bank RA, Pals G, Ankala A, Conneely K, Seaver L, et al. (2013) Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen. Hum Mol Genet 22, 117.
  • 19
    Kaye DM, Khammy O, Mariani J & Maeder MT (2013) Relationship of circulating matrix biomarkers to myocardial matrix metabolism in advanced heart failure. Eur J Heart Fail 3, 292298.
  • 20
    Sundstrom J, Evans JC, Benjamin EJ, Levy D, Larson MG, Sawyer DB, Siwik DA, Colucci WS, Wilson PW & Vasan RS (2004) Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study. Eur Heart J 25, 15091516.
  • 21
    Yeh JT, Yeh LK, Jung SM, Chang TJ, Wu HH, Shiu TF, Liu CY, Kao WW & Chu PH (2010) Impaired skin wound healing in lumican-null mice. Br J Dermatol 163, 11741180.
  • 22
    Li LF, Chen BX, Tsai YH, Kao WW, Yang CT & Chu PH (2011) Lumican expression in diaphragm induced by mechanical ventilation. PLoS One 6, e24692.
  • 23
    Nikitovic D, Chalkiadaki G, Berdiaki A, Aggelidakis J, Katonis P, Karamanos NK & Tzanakakis GN (2011) Lumican regulates osteosarcoma cell adhesion by modulating TGFbeta2 activity. Int J Biochem Cell Biol 43, 928935.
  • 24
    Lohr K, Sardana H, Lee S, Wu F, Huso DL, Hamad AR & Chakravarti S (2012) Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis. Inflamm Bowel Dis 18, 143151.
  • 25
    Wang J, Markova D, Anderson DG, Zheng Z, Shapiro IM & Risbud MV (2011) TNF-alpha and IL-1beta promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J Biol Chem 286, 3973839749.
  • 26
    Hwang JJ, Allen PD, Tseng GC, Lam CW, Fananapazir L, Dzau VJ & Liew CC (2002) Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiol Genomics 10, 3144.
  • 27
    Souders CA, Bowers SL & Baudino TA (2009) Cardiac fibroblast: the renaissance cell. Circ Res 105, 11641176.
  • 28
    Bouzegrhane F & Thibault G (2002) Is angiotensin II a proliferative factor of cardiac fibroblasts? Cardiovasc Res 53, 304312.
  • 29
    Yang F, Dong A, Mueller P, Caicedo J, Sutton AM, Odetunde J, Barrick CJ, Klyachkin YM, Abdel-Latif A & Smyth SS (2012) Coronary artery remodeling in a model of left ventricular pressure overload is influenced by platelets and inflammatory cells. PLoS One 7, e40196.
  • 30
    Gullestad L, Ueland T, Vinge LE, Finsen A, Yndestad A & Aukrust P (2012) Inflammatory cytokines in heart failure: mediators and markers. Cardiology 122, 2335.
  • 31
    Rauchhaus M, Doehner W, Francis DP, Davos C, Kemp M, Liebenthal C, Niebauer J, Hooper J, Volk HD, Coats AJ, et al. (2000) Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation 102, 30603067.
  • 32
    Charalambous BM, Stephens RC, Feavers IM & Montgomery HE (2007) Role of bacterial endotoxin in chronic heart failure: the gut of the matter. Shock 28, 1523.
  • 33
    Lemire JM, Chan CK, Bressler S, Miller J, LeBaron RG & Wight TN (2007) Interleukin-1beta selectively decreases the synthesis of versican by arterial smooth muscle cells. J Cell Biochem 101, 753766.
  • 34
    Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, et al. (2012) Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1. Eur Heart J 33, 23602369.
  • 35
    Herum KM, Lunde IG, Skrbic B, Florholmen G, Behmen D, Sjaastad I, Carlson CR, Gomez MF & Christensen G (2013) Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress. J Mol Cell Cardiol 54, 7381.
  • 36
    Rohr S (2011) Cardiac fibroblasts in cell culture systems: myofibroblasts all along? J Cardiovasc Pharmacol 57, 389399.
  • 37
    Goldsmith EC, Bradshaw AD & Spinale FG (2013) Contributory pathways leading to myocardial fibrosis – moving beyond collagen expression. Am J Physiol Cell Physiol 304, 393402.
  • 38
    Chakravarti S, Magnuson T, Lass JH, Jepsen KJ, LaMantia C & Carroll H (1998) Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. J Cell Biol 141, 12771286.
  • 39
    Lopez B, Querejeta R, Gonzalez A, Larman M & Diez J (2012) Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase. Hypertension 60, 677683.
  • 40
    Siegel RC (1976) Collagen cross-linking. Synthesis of collagen cross-links in vitro with highly purified lysyl oxidase. J Biol Chem 251, 57865792.
  • 41
    Lucas JA, Zhang Y, Li P, Gong K, Miller AP, Hassan E, Hage F, Xing D, Wells B, Oparil S, et al. (2010) Inhibition of transforming growth factor-beta signaling induces left ventricular dilation and dysfunction in the pressure-overloaded heart. Am J Physiol Heart Circ Physiol 298, H424H432.
  • 42
    Xia Y, Lee K, Li N, Corbett D, Mendoza L & Frangogiannis NG (2009) Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload. Histochem Cell Biol 131, 471481.
  • 43
    Hein S, Arnon E, Kostin S, Schonburg M, Elsasser A, Polyakova V, Bauer EP, Klovekorn WP & Schaper J (2003) Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 107, 984991.
  • 44
    Oh CJ, Kim JY, Choi YK, Kim HJ, Jeong JY, Bae KH, Park KG & Lee IK (2012) Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta/Smad signaling. PLoS One 7, e45870.
  • 45
    Dobaczewski M, Bujak M, Li N, Gonzalez-Quesada C, Mendoza LH, Wang XF & Frangogiannis NG (2010) Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res 107, 418428.
  • 46
    Krishnan A, Li X, Kao WY, Viker K, Butters K, Masuoka H, Knudsen B, Gores G & Charlton M (2012) Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis. Lab Invest 92, 17121725.
  • 47
    Markmann A, Hausser H, Schonherr E & Kresse H (2000) Influence of decorin expression on transforming growth factor-beta-mediated collagen gel retraction and biglycan induction. Matrix Biol 19, 631636.
  • 48
    Bjørnstad JL, Skrbic B, Marstein HS, Hasic A, Sjaastad I, Louch WE, Florholmen G, Christensen G & Tønnessen T (2012) Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload. Cardiovasc Res 93, 100110.
  • 49
    Williams KE, Fulford LA & Albig AR (2010) Lumican reduces tumor growth via induction of fas-mediated endothelial cell apoptosis. Cancer Microenviron 4, 115126.
  • 50
    Chandrasekar B, Mummidi S, Mahimainathan L, Patel DN, Bailey SR, Imam SZ, Greene WC & Valente AJ (2006) Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin. J Biol Chem 281, 1509915109.
  • 51
    Li J, Lau G, Chen L, Yuan YF, Huang J, Luk JM, Xie D & Guan XY (2012) Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression. PLoS One 7, e46264.
  • 52
    Spinale FG (2007) Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev 87, 12851342.
  • 53
    Polyakova V, Loeffler I, Hein S, Miyagawa S, Piotrowska I, Dammer S, Risteli J, Schaper J & Kostin S (2011) Fibrosis in endstage human heart failure: severe changes in collagen metabolism and MMP/TIMP profiles. Int J Cardiol 151, 1833.
  • 54
    Murphy G & Nagase H (2011) Localizing matrix metalloproteinase activities in the pericellular environment. FEBS J 278, 215.
  • 55
    Batlle M, Perez-Villa F, Garcia-Pras E, Lazaro A, Orus J, Roque M & Roig E (2007) Down-regulation of matrix metalloproteinase-9 (MMP-9) expression in the myocardium of congestive heart failure patients. Transplant Proc 39, 23442346.
  • 56
    Niewiarowska J, Brezillon S, Sacewicz-Hofman I, Bednarek R, Maquart FX, Malinowski M, Wiktorska M, Wegrowski Y & Cierniewski CS (2011) Lumican inhibits angiogenesis by interfering with alpha2beta1 receptor activity and downregulating MMP-14 expression. Thromb Res 128, 452457.
  • 57
    Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly RA, Werb Z, Libby P, et al. (2000) Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest 106, 5562.
  • 58
    Kennedy A, Hennessy M, Bergin C, Mulcahy F, Hopkins S & Spiers JP (2011) Ribavirin and interferon alter MMP-9 abundance in vitro and in HIV–HCV-coinfected patients. Antivir Ther 16, 12371247.
  • 59
    Hadler-Olsen E, Fadnes B, Sylte I, Uhlin-Hansen L & Winberg JO (2011) Regulation of matrix metalloproteinase activity in health and disease. FEBS J 278, 2845.
  • 60
    Iozzo RV & Schaefer L (2010) Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans. FEBS J 277, 38643875.
  • 61
    Bjørnstad JL, Sjaastad I, Nygard S, Hasic A, Ahmed MS, Attramadal H, Finsen AV, Christensen G & Tønnessen T (2011) Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload. Eur Heart J 32, 236245.
  • 62
    Bjørnstad JL, Skrbic B, Sjaastad I, Bjørnstad S, Christensen G & Tønnessen T (2012) A mouse model of reverse cardiac remodelling following banding-debanding of the ascending aorta. Acta Physiol (Oxford) 205, 92102.
  • 63
    Yndestad A, Finsen AV, Ueland T, Husberg C, Dahl CP, Oie E, Vinge LE, Sjaastad I, Sandanger O, Ranheim T, et al. (2012) The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure. PLoS One 7, e33038.
  • 64
    Finsen AV, Lunde IG, Sjaastad I, Ostli EK, Lyngra M, Jarstadmarken HO, Hasic A, Nygard S, Wilcox-Adelman SA, Goetinck PF, et al. (2011) Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway. PLoS One 6, e28302.
  • 65
    Seidler DG, Schaefer L, Robenek H, Iozzo RV, Kresse H & Schonherr E (2005) A physiologic three-dimensional cell culture system to investigate the role of decorin in matrix organisation and cell survival. Biochem Biophys Res Commun 332, 11621170.