• 1
    Hanahan D & Weinberg RA (2000) The hallmarks of cancer. Cell 100, 5770.
  • 2
    Nigg EA (1995) Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. BioEssays 6, 471480.
  • 3
    Nicholson DW (1999) Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 11, 10281042.
  • 4
    Berridge MJ, Lipp P & Bootman MD (2000) The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1, 1121.
  • 5
    Berridge MJ, Bootman MD & Roderick HL (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 7, 517529.
  • 6
    Allbritton NL, Meyer T & Stryer L (1992) Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate. Science 258, 18121815.
  • 7
    Amin N & Vincan E (2012) The Wnt signaling pathways and cell adhesion. Front Biosci 17, 784804.
  • 8
    Prevarskaya N, Skryma R & Shuba Y (2011) Calcium in tumour metastasis: new roles for known actors. Nat Rev Cancer 11, 609618.
  • 9
    Vanoverberghe K, Lehen'kyi V, Thébault S, Raphaël M, Vanden Abeele F, Slomianny C, Mariot P & Prevarskaya N (2012) Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells. PLoS One 7, e45615.
  • 10
    Whitfield JF (2009) The calcium-sensing receptor – a driver of colon cell differentiation. Curr Pharm Biotechnol 10, 311316.
  • 11
    Capiod T, Shuba Y, Skryma R & Prevarskaya N (2008) Calcium signalling and cancer cell growth. Subcell Biochem 45, 405427.
  • 12
    Capiod T (2011) Cell proliferation, calcium influx and calcium channels. Biochimie 12, 20752079.
  • 13
    Orrenius S, Zhivotovsky B & Nicotera P (2003) Regulation of cell death: the calcium–apoptosis link. Nat Rev Mol Cell Biol 4, 552565.
  • 14
    Estaquier J, Vallette F, Vayssiere JL & Mignotte B (2012) The mitochondrial pathways of apoptosis. Adv Exp Med Biol 942, 157183.
  • 15
    Rufini A & Melino G (2011) Cell death pathology: the war against cancer. Biochem Biophys Res Commun 414, 445450.
  • 16
    Prevarskaya N, Skryma R, Bidaux G, Flourakis M & Shuba Y (2007) Ion channels in death and differentiation of prostate cancer cells. Cell Death Differ 14, 12951304.
  • 17
    Kaufmann T, Strasser A & Jost PJ (2012) Fas death receptor signalling: roles of Bid and XIAP. Cell Death Differ 19, 4250.
  • 18
    Prevarskaya N, Skryma R & Shuba Y (2004) Ca2+ homeostasis in apoptotic resistance of prostate cancer cells. Biochem Biophys Res Commun 322, 13261335.
  • 19
    McConkey DJ & Orrenius S (1997) The role of calcium in the regulation of apoptosis. Biochem Biophys Res Commun 239, 357366.
  • 20
    Vanden Abeele F, Skryma R, Shuba Y, Van Coppenolle F, Slomianny C, Roudbaraki M, Mauroy B, Wuytack F & Prevarskaya N (2002) Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells. Cancer Cell 1, 169179.
  • 21
    Lewis RS (2003) Calcium oscillations in T-cells: mechanisms and consequences for gene expression. Biochem Soc Trans 31, 925929.
  • 22
    Wei C, Wang X, Zheng M & Cheng H (2012) Calcium gradients underlying cell migration. Curr Opin Cell Biol 24, 254261.
  • 23
    Parkash J & Asotra K (2010) Calcium wave signaling in cancer cells. Life Sci 87, 587595.
  • 24
    Strehler EE, Filoteo AG, Penniston JT & Caride AJ (2007) Plasma-membrane Ca(2+) pumps: structural diversity as the basis for functional versatility. Biochem Soc Trans 35, 919922.
  • 25
    Roberts-Thomson SJ, Curry MC & Monteith GR (2010) Plasma membrane calcium pumps and their emerging roles in cancer. World J Biol Chem 1, 248253.
  • 26
    Curry MC, Roberts-Thomson SJ & Monteith GR (2011) Plasma membrane calcium ATPases and cancer. BioFactors 37, 132138.
  • 27
    VanHouten J, Sullivan C, Bazinet C, Ryoo T, Camp R, Rimm DL, Chung G & Wysolmerski J (2010) PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer. Proc Natl Acad Sci USA 107, 1140511410.
  • 28
    Lee WJ, Roberts-Thomson SJ & Monteith GR (2005) Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines. Biochem Biophys Res Commun 337, 779783.
  • 29
    Curry MC, Luk NA, Kenny PA, Roberts-Thomson SJ & Monteith GR (2012) Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer cells. J Biol Chem 287, 2859828608.
  • 30
    Fernandes D, Zaidi A, Bean J, Hui D & Michaelis ML (2007) RNA-induced silencing of the plasma membrane Ca2+-ATPase 2 in neuronal cells: effects on Ca2+ homeostasis and cell viability. J Neurochem 102, 454465.
  • 31
    Baggott RR, Mohamed TM, Oceandy D, Holton M, Blanc MC, Roux-Soro SC, Brown S, Brown JE, Cartwright EJ, Wang W et al. (2012) Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells. Carcinogenesis 33, 23622368.
  • 32
    Aung CS, Ye W, Plowman G, Peters AA, Monteith GR & Roberts-Thomson SJ (2009) Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells. Carcinogenesis 30, 19621969.
  • 33
    Venkatachalam K & Montell C (2007) TRP channels. Annu Rev Biochem 76, 387417.
  • 34
    Schindl R, Kahr H, Graz I, Groschner K & Romanin C (2002) Store depletion-activated CaT1 currents in rat basophilic leukemia mast cells are inhibited by 2-aminoethoxydiphenyl-borate. Evidence for a regulatory component that controls activation of both CaT1 and CRAC (Ca(2+) release-activated Ca(2+) channel) channels. J Biol Chem 277, 2695026958.
  • 35
    Bodding M & Flockerzi V (2004) Ca2+ dependence of the Ca2+-selective TRPV6 channel. J Biol Chem 279, 3654636552.
  • 36
    Vanden Abeele F, Lemonnier L, Thébault S, Lepage G, Parys JB, Shuba Y, Skryma R & Prevarskaya N (2004) Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells. J Biol Chem 279, 3032630337.
  • 37
    Lehen'kyi V, Flourakis M, Skryma R & Prevarskaya N (2007) TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways. Oncogene 26, 73807385.
  • 38
    Skryma R, Mariot P, Bourhis XL et al. (2000) Store depletion and store-operated Ca2+ current in human prostate cancer LNCaP cells: involvement in apoptosis. J Physiol 527, 7183.
  • 39
    Flourakis M, Lehen'kyi V, Beck B, Raphaël M, Vandenberghe M, Abeele FV, Roudbaraki M, Lepage G, Mauroy B, Romanin C et al. (2010) Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells. Cell Death Dis 1, e75.
  • 40
    Faouzi M, Hague F, Potier M, Ahidouch A, Sevestre H & Ouadid-Ahidouch H (2011) Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells. J Cell Physiol 226, 542551.
  • 41
    Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF et al. (2011) CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation. Proc Natl Acad Sci USA 108, 1907219077.
  • 42
    Corvazier E, Bredoux R, Kovács T & Enouf J (2009) Expression of sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) 3 proteins in two major conformational states in native human cell membranes. Biochim Biophys Acta 1788, 587599.
  • 43
    Korosec B, Glavac D, Volavsek M & Ravnik-Glavac M (2009) ATP2A3 gene is involved in cancer susceptibility. Cancer Genet Cytogenet 188, 8894.
  • 44
    Korosec B, Glavac D, Volavsek M & Ravnik-Glavac M (2008) Alterations in genes encoding sarcoplasmic–endoplasmic reticulum Ca2+ pumps in association with head and neck squamous cell carcinoma. Cancer Genet Cytogenet 181, 112118.
  • 45
    Boehning D, Patterson RL & Snyder SH (2004) Apoptosis and calcium: new roles for cytochrome c and inositol 1,4,5-trisphosphate. Cell Cycle 3, 252254.
  • 46
    Wegierski T, Steffl D, Kopp C, Tauber R, Buchholz B, Nitschke R, Kuehn EW, Walz G & Köttgen M (2009) TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum. EMBO J 28, 490499.
  • 47
    McConkey DJ, Lin Y, Nutt LK, Ozel HZ & Newman RA (2000) Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. Cancer Res 60, 38073812.
  • 48
    Newman RA, Yang P, Pawlus AD & Block KI (2008) Cardiac glycosides as novel cancer therapeutic agents. Mol Interv 8, 3649.
  • 49
    Kim HL & Im DS (2008) N,N-dimethyl-d-erythro-sphingosine increases intracellular Ca2+ concentration via Na+–Ca2+-exchanger in HCT116 human colon cancer cells. Arch Pharm Res 31, 5459.
  • 50
    Falschlehner C, Ganten TM, Koschny R, Schaefer U & Walczak H (2009) TRAIL and other TRAIL receptor agonists as novel cancer therapeutics. Adv Exp Med Biol 647, 195206.
  • 51
    Gerspach J, Pfizenmaier K & Wajant H (2011) Therapeutic targeting of CD95 and the TRAIL death receptors. Recent Pat Anticancer Drug Discov 6, 294310.
  • 52
    Kirkin V, Cahuzac N, Guardiola-Serrano F, Huault S, Lückerath K, Friedmann E, Novac N, Wels WS, Martoglio B, Hueber AO et al. (2007) The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. Cell Death Differ 14, 16781687.
  • 53
    Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O & Saftig P (2007) ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death. Cell Death Differ 14, 10401049.
  • 54
    Chow J, Norng M, Zhang J & Chai J (2007) TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells. Mechanisms behind a possible new ‘hot’ cancer treatment. Biochim Biophys Acta 1773, 565576.
  • 55
    Xu ZW, Wang FM, Gao MJ, Chen XY, Hu WL & Xu RC (2010) Targeting the Na(+)/K(+)-ATPase alpha1 subunit of hepatoma HepG2 cell line to induce apoptosis and cell cycle arresting. Biol Pharm Bull 33, 743751.
  • 56
    Wang W, Xiao J, Adachi M, Liu Z & Zhou J (2011) 4-Aminopyridine induces apoptosis of human acute myeloid leukemia cells via increasing [Ca2+]i through P2X7 receptor pathway. Cell Physiol Biochem 28, 199208.
  • 57
    Vaish V & Sanyal SN (2012) Role of Sulindac and Celecoxib in chemoprevention of colorectal cancer via intrinsic pathway of apoptosis: exploring NHE-1, intracellular calcium homeostasis and calpain 9. Biomed Pharmacother 66, 116130.
  • 58
    Muscella A, Calabriso N, Vetrugno C, Fanizzi FP, De Pascali SA, Storelli C & Marsigliante S (2011) The platinum (II) complex [Pt(O, O′-acac)(γ-acac)(DMS)] alters the intracellular calcium homeostasis in MCF-7 breast cancer cells. Biochem Pharmacol 81, 91103.
  • 59
    Pande J, Szewczyk MM & Grover AK (2011) Allosteric inhibitors of plasma membrane Ca pumps: invention and applications of caloxins. World J Biol Chem 2, 3947.
  • 60
    Schwarze SR, Lin EW, Christian PA, Gayheart DT & Kyprianou N (2008) Intracellular death platform steps-in: targeting prostate tumors via endoplasmic reticulum (ER) apoptosis. Prostate 68, 16151623.
  • 61
    Denmeade SR, Jakobsen CM, Janssen S, Khan SR, Garrett ES, Lilja H, Christensen SB & Isaacs JT (2003) Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer. J Natl Cancer Inst 95, 9901000.
  • 62
    Denmeade SR, Mhaka AM, Rosen DM, Brennen WN, Dalrymple S, Dach I, Olesen C, Gurel B, Demarzo AM, Wilding G et al. (2012) Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy. Sci Transl Med 4, 140186.
  • 63
    Winther AM, Liu H, Sonntag Y, Olesen C, le Maire M, Soehoel H, Olsen CE, Christensen SB, Nissen P & Møller JV (2010) Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs. J Biol Chem 285, 2888328892.
  • 64
    Mandic A, Hansson J, Linder S & Shoshan MC (2003) Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 278, 91009106.
  • 65
    Zhang W, Couldwell WT, Song H, Takano T, Lin JH & Nedergaard M (2000) Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells. Cancer Res 60, 53955400.
  • 66
    Liang WZ & Lu CH (2012) Carvacrol-induced [Ca2+]i rise and apoptosis in human glioblastoma cells. Life Sci 90, 703711.
  • 67
    Valiahdi SM, Heffeter P, Jakupec MA, Marculescu R, Berger W, Rappersberger K & Keppler BK (2009) The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines. Melanoma Res 19, 283293.
  • 68
    Kumar B, Kumar A, Ghosh S, Pandey BN, Mishra KP & Hazra B (2012) Diospyrin derivative, an anticancer quinonoid, regulates apoptosis at endoplasmic reticulumas well as mitochondria by modulating cytosolic calcium in human breast carcinoma cells. Biochem Biophys Res Commun 417, 903909.
  • 69
    Park IJ, Kim MJ, Park OJ, Choe W, Kang I, Kim SS & Ha J (2012) Cryptotanshinone induces ER stress-mediated apoptosis in HepG2 and MCF7 cells. Apoptosis 17, 248257.
  • 70
    Tian F, Schrödl K, Kiefl R, Huber RM & Bergner A (2012) The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+ homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells. Anticancer Res 32, 8994.
  • 71
    Distelhorst CW & Bootman MD (2011) Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca2+ signaling and disease. Cell Calcium 50, 234241.
  • 72
    Rong YP, Aromolaran AS, Bultynck G, Zhong F, Li X, McColl K, Matsuyama S, Herlitze S, Roderick HL, Bootman MD et al. (2008) Targeting Bcl-2–IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals. Mol Cell 31, 255265.