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Fig. S1. Susceptibility of antigenomic delta ribozyme to Pb2+ -induced cleavage in the presence of 0.5 mm amikacin (Ami), neomycin B (Neo), and actinomycin D (Actin), and their complexes with Cu2 + .

Fig. S2. Probing of the cleaved form of antigenomic delta ribozyme in the presence of amikacin (Ami), neomycin B (Neo), and actinomycin D (Actin), and their complexes with Cu2+, with nuclease S1.

Fig. S3. Probing of the cleaved form of antigenomic delta ribozyme with nuclease S1.

Fig. S4. Normalized SHAPE reactivities as a function of nucleotide position in the cleaved form of antigenomic delta ribozyme.

Fig. S5. Normalized SHAPE reactivities as a function of nucleotide position in the uncleaved form of antigenomic delta ribozyme.

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