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Fig. S1. 1H NMR spectrum of the metabolite formed by CYP2D6_E216F_F483G. The assignments of the resonances to 2,17-dihydroxy-, (2β,17β)-androst-4-en-3-one are indicated.

Doc. S1. Modification of synthetic CYP2D6 variants.

Table S1. Relative testosterone hydroxylase activities of all 400 CYP2D6 mutants generated in this study.

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