What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

Authors

  • Alex Perálvarez-Marín,

    Corresponding author
    1. Centre d'Estudis en Biofísica, Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Spain
    • Correspondence

      A. Perálvarez-Marín, Centre d'Estudis en Biofísica, Unitat de Biofísica, Departament de Bioquímica i de Biologia Molecular, Edifici M, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Spain

      Fax: +34 9358 11907

      Tel: +34 93581 4504

      E-mail: peralvarezmarin@gmail.com

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  • Pau Doñate-Macian,

    1. Centre d'Estudis en Biofísica, Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Spain
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  • Rachelle Gaudet

    1. Department of Molecular and Cell Biology, Harvard University, Cambridge, MA, USA
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Abstract

Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell physiology. The vanilloid TRP subfamily (TRPV) named after the vanilloid receptor 1 (TRPV1) consists of six members, and at least four of them (TRPV1–TRPV4) have been related to thermal sensation. One of the least characterized members of the TRP subfamily is TRPV2. Although initially characterized as a noxious heat sensor, TRPV2 now seems to have little to do with temperature sensing but a much more complex physiological profile. Here we review the available information and research progress on the structure, physiology and pharmacology of TRPV2 in an attempt to shed some light on the physiological and pharmacological deorphanization of TRPV2.

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