Endosomal trafficking of the receptor tyrosine kinase MuSK proceeds via clathrin-dependent pathways, Arf6 and actin
Article first published online: 23 MAY 2013
© 2013 The Authors. FEBS Journal published by John Wiley & Sons Ltd on behalf of FEBS
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Volume 280, Issue 14, pages 3281–3297, July 2013
How to Cite
Luiskandl, S., Woller, B., Schlauf, M., Schmid, J. A. and Herbst, R. (2013), Endosomal trafficking of the receptor tyrosine kinase MuSK proceeds via clathrin-dependent pathways, Arf6 and actin. FEBS Journal, 280: 3281–3297. doi: 10.1111/febs.12309
- Issue published online: 5 JUL 2013
- Article first published online: 23 MAY 2013
- Accepted manuscript online: 27 APR 2013 06:54AM EST
- Manuscript Accepted: 19 APR 2013
- Manuscript Revised: 12 APR 2013
- Manuscript Received: 23 DEC 2012
- Austrian Science Fund . Grant Number: P19223 and P21667
|febs12309-sup-0001-FigureS1-S7_docS1.zip||application/ZIP||4606K||Doc. S1. Supplementary materials and methods. Fig. S1. MuSK turnover in COS-7 cells and C2 myotubes. Fig. S2. MuSK colocalization with clathrin and lipid raft markers and transferrin internalization in the presence of clathrin and dynamin inhibitors. Fig. S3. Rab11 regulates MuSK recycling. Fig. S4. MuSK endocytosis involves the actin cytoskeleton and Arf6. Fig. S5. The MuSK internalization is not altered upon cytochalasin D treatment or the expression of Arf6. Fig. S6. MuSK activation by Dok7 and its colocalization with pTyr, Arf6 and endosomal markers. Fig. S7. Agrin-induced AChR clustering is not affected in Myr-Arf1 treated myotubes.|
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