Expanding functions of intracellular resident mono-ADP-ribosylation in cell physiology

Authors

  • Karla L. H. Feijs,

    1. Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Germany
    Search for more papers by this author
    • These authors contributed equally to this paper
  • Patricia Verheugd,

    1. Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Germany
    Search for more papers by this author
    • These authors contributed equally to this paper
  • Bernhard Lüscher

    Corresponding author
    1. Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Germany
    • Correspondence

      B. Lüscher, Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany

      Fax: +49 241 8082427

      Tel: +49 241 8088850

      E-mail: Luescher@rwth-aachen.de

    Search for more papers by this author

Abstract

Poly-ADP-ribosylation functions in diverse signaling pathways, such as Wnt signaling and DNA damage repair, where its role is relatively well characterized. Contrarily, mono-ADP-ribosylation by for example ARTD10/PARP10 is much less understood. Recent developments hint at the involvement of mono-ADP-ribosylation in transcriptional regulation, the unfolded protein response, DNA repair, insulin secretion and immunity. Additionally, macrodomain-containing hydrolases, MacroD1, MacroD2 and C6orf130/TARG1, have been identified that make mono-ADP-ribosylation reversible. Complicating further progress is the lack of tools such as mono-ADP-ribose-specific antibodies. The currently known functions of mono-ADP-ribosylation are summarized here, as well as the available tools such as mass spectrometry to study this modification in vitro and in cells.

Ancillary