Note Pura Muñoz-Cánoves and Antonio L. Serrano contributed equally to this work
Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
Article first published online: 18 JUN 2013
© 2013 The Authors. FEBS Journal published by John Wiley & Sons Ltd on behalf of FEBS
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Special Issue: Myogenesis
Volume 280, Issue 17, pages 4131–4148, September 2013
How to Cite
Muñoz-Cánoves, P., Scheele, C., Pedersen, B. K. and Serrano, A. L. (2013), Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?. FEBS Journal, 280: 4131–4148. doi: 10.1111/febs.12338
- Issue published online: 20 AUG 2013
- Article first published online: 18 JUN 2013
- Accepted manuscript online: 13 MAY 2013 12:11AM EST
- Manuscript Accepted: 7 MAY 2013
- Manuscript Revised: 25 APR 2013
- Manuscript Received: 28 FEB 2013
- MICINN. Grant Numbers: SAF2009-09782, FIS-PS09/01267, SAF2012-38547, PLE2009-0124
- Danish National Research Foundation. Grant Number: DNRF55
- satellite cell;
- signaling pathway;
- skeletal muscle
Interleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. Muscle is also an important target of the cytokine. IL-6 signaling has been associated with stimulation of hypertrophic muscle growth and myogenesis through regulation of the proliferative capacity of muscle stem cells. Additional beneficial effects of IL-6 include regulation of energy metabolism, which is related to the capacity of actively contracting muscle to synthesize and release IL-6. Paradoxically, deleterious actions for IL-6 have also been proposed, such as promotion of atrophy and muscle wasting. We review the current evidence for these apparently contradictory effects, the mechanisms involved and discuss their possible biological implications.