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Fig. S1. SIRT7 localization and expression.

Fig. S2. SIRT7 detection by sub-cellular fractionation and following knockdown.

Fig. S3. Expression pattern of 45 and 47.5 kDa following cell cycle synchronization,and treatment with okadaic acid and calf intestinal phosphatase.

Fig. S4. Identification of nuclear and nucleolar localization regions of SIRT7 using N- and C-terminal deletion constructs.

Fig. S5. Amino acid sequence alignment of SIRT7 nuclear and nucleolar localization signals with previously validated localization signals of other proteins.

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