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Fig. S1. V-ATPase inhibitors or chloroquine suppress to various extents TRAIL-induced apoptotic signalling in a number of human cancer cell lines.

Fig. S2. The inhibitory effect of bafilomycin A1 is fast and affects the proximal TRAIL-induced activation of caspase-8.

Fig. S3. Effect of concanamycin A on the distribution and trafficking of TRAIL-containing endosomes in DLD-1 cells.

Fig. S4. Downregulation of Rab7 GTPase has no effect on the activation of proximal TRAIL-induced apoptotic signalling.

Fig. S5. C18 sphingosine did not reverse the BafA1-mediated suppression of TRAIL-induced apoptotic signalling.

Fig. S6. Bafilomycin A1 treatment does not alter the cell surface expression of death receptors or the kinetics of their TRAIL-induced internalization in DLD-1 and Colo206F cells.

Fig. S7. Effect of suppressed endosomal acidification on the cleavage/processing of several apoptosis-related proteins and TRAIL-induced pro-survival signalling in DLD-1 and Colo206F cells.

Table S1. Sequences of short inhibitory RNAs in the shRNA-expressing lentiviral pLKO1-based vectors used for downregulation of cFLIP in DLD-1 cells.

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