Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor
Article first published online: 2 AUG 2013
© 2013 FEBS
Special Issue: Frontiers in Cell Signalling, and Ca2+-Signalling and Transport in Health and Disease
Volume 280, Issue 21, pages 5283–5297, November 2013
How to Cite
Etemadi, N., Holien, J. K., Chau, D., Dewson, G., Murphy, J. M., Alexander, W. S., Parker, M. W., Silke, J. and Nachbur, U. (2013), Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor. FEBS Journal, 280: 5283–5297. doi: 10.1111/febs.12419
- Issue published online: 15 OCT 2013
- Article first published online: 2 AUG 2013
- Accepted manuscript online: 2 JUL 2013 03:42AM EST
- Manuscript Accepted: 28 JUN 2013
- Manuscript Revised: 8 MAY 2013
- Manuscript Received: 25 JAN 2013
- National Health and Medical Research Council of Australia. Grant Numbers: 541901, 541902, 602516, 637342, 1025594, 1016647, 575501
- Independent Research Institutes Infrastructure Support Scheme. Grant Number: 361646
- Australian National Health and Medical Research Council
- Australian Cancer Research Fund
- Victorian State Government Operational Infrastructure Support
- Australian Research Council. Grant Number: FT100100100
- Swiss National Science Foundation. Grant Number: 00P3_126249
Fig. S1. Chromosomal regions, alignment of human and mouse TNF and LTα protein sequences and oligomeric states of TNF and LTα.
Fig. S2. Cell death induction by TNF and LTα.
Fig. S3. TNF and LTα activate the NF-κB transcription factor similarly.
Fig. S4. Bone marrow-derived macrophages respond similarly to LTα and TNF stimulation via TNFR1.
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