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Fig. S1. SAHF formation in MDA-MB-231 and A549 cells after infection and cleaved caspase 3 protein levels after treatment.

Fig. S2. Dox- and SN-38-induced senescence in MDA-MB-435 cells.

Fig. S3. Western blots of phospho-Rb (pSer807/811) levels in MDA-MB-231 and MDA-MB-435 cells after treatment and western blots of the phospho-Rb (pSer807/811) and Rb levels in normal and senescent WI38 cells.

Fig. S4. Verification of the efficiency of Rb siRNA in MDA-MB-231 cells, the suppression efficiency of SB203580 in MDA-MB-231 cells, expression of HBP1 in young and old WI38 cells and verification of the efficiency of HBP1 siRNA in MDA-MB-231 cells.

Fig. S5. Verification of the enrichment of HBP1 on E2F1 targets using ChIP assays and effect of blockage of p38 MAPK by SB203580.

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