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Doc. S1. Drug validation.

Fig. S1. Localization of FLAG-Cdc45 and FLAG-Cdc45 mutants.

Fig. S2. Co-immunoprecipitation of FLAG-Cdc45 deletion mutants with replication proteins.

Fig. S3. Densitometry analysis of the Cdc45–Claspin interaction in the cell cycle.

Fig. S4. Densitometry analysis of the Cdc45–Claspin interaction after UVC treatment.

Fig. S5. FLAG immunoprecipitation in the presence of UCN-01.

Fig. S6. Validation of UCN-01 efficacy.

Fig. S7. Validation of caffeine efficacy.

Fig. S8. KU-55933 treatment does not rescue the Cdc45–Claspin interaction after UVC treatment.

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